Evidence map›Paper›PMID 37160317›Full record

ArticleCold Spring Harbor molecular case studies2023

Melanoma in a patient with DNMT3A overgrowth syndrome.

David Y Chen, Leslie A Sutton, Sai Mukund Ramakrishnan, Eric J Duncavage, Sharon E Heath, Leigh A Compton, Christopher A Miller, Timothy J Ley

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

David Y ChenDivision of Dermatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA; davidchen@wustl.edu.ORCID 0000-0002-3681-6576
Leslie A SuttonDivision of Dermatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0002-6812-0880
Sai Mukund RamakrishnanDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0002-4500-6583
Eric J DuncavageDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0003-4199-8906
Sharon E HeathDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Leigh A ComptonDivision of Dermatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0001-6808-3103
Christopher A MillerDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0003-4266-6700
Timothy J LeyDivision of Oncology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Washington University in St. Louis · US

Funding

Specimen Acquistition and Expression ProfilingP01CA101937 · NCI · WASHINGTON UNIVERSITY · PI LINK, DANIEL C · 2003 to 2023
$58.8M
Molecular Pathogenesis of Acute Myeloid LeukemiaR35CA197561 · NCI · WASHINGTON UNIVERSITY · PI Timothy J. Ley · 2015 to 2026
$11.0M
COMPREHENSIVE INFORMATIC ANALYSES OF AML GENOMES AND EPIGENOMESR50CA211782 · NCI · WASHINGTON UNIVERSITY · PI Christopher A Miller · 2017 to 2026
$1.5M
Epigenetic Regulation of Cutaneous TumorigenesisK08CA237727 · NCI · WASHINGTON UNIVERSITY · PI CHEN, DAVID · 2020 to 2024
$1.2M
NCI NIH HHS K08 CA237727NCI NIH HHS P01 CA101937NCI NIH HHS R35 CA197561NCI NIH HHS R50 CA211782
6 · The paper itself

Abstract

Alterations in epigenetic regulators are increasingly recognized as early events in tumorigenesis; thus, patients with acquired or inherited variants in epigenetic regulators may be at increased risk for developing multiple types of cancer. DNMT3A overgrowth syndrome (DOS), caused by germline pathogenic variants in the DNA methyltransferase gene

Indexed as

MelanomaNeoplasms, Second PrimaryCell ProliferationDNA Methyltransferase 3ADNA Modification MethylasesGenotypeHumansSyndromeDNA Methyltransferase 3ADNA Modification MethylasesDNMT3A protein, humancutaneous melanomaovergrowth

Identifiers

PMID37160317
PMCPMC10240841
OpenAlexW4376133564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.