Evidence map›Paper›PMID 37160316›Full record

ArticleCold Spring Harbor molecular case studies2023

Clonal cytopenia of undetermined significance (CCUS)-associated reversion of donor-derived, transient αβ T-cell large granular clonal lymphocytosis, emerging post-transplant in a patient with a history of γδ T-cell large granular lymphocytic leukemia.

Siba El Hussein, Andrew G Evans, John M Fitzsimmons, Nufatt Leong, Meghan Buldo, Jeremy P Segal, Audrey N Jajosky, Paul G Rothberg, Jane L Liesveld, Zoltán N Oltvai

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PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Siba El HusseinDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA; elhusseinsiba@gmail.com zoltan_oltvai@urmc.rochester.edu.ORCID 0000-0002-1338-7107
Andrew G EvansDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
John M FitzsimmonsDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Nufatt LeongDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Meghan BuldoDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Jeremy P SegalDepartment of Pathology, University of Chicago Medicine, Chicago, Illinois 60637, USA.
Audrey N JajoskyDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Paul G RothbergDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Jane L LiesveldDepartment of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
Zoltán N OltvaiDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA; elhusseinsiba@gmail.com zoltan_oltvai@urmc.rochester.edu.
University of Rochester Medical Center · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) has revolutionized the therapy of hematolymphoid malignancies. Yet, how to best detect or predict the emergence of HSCT-related complications remain unresolved. Here, we describe a case of donor-derived, transient Alpha Beta (αβ) T-cell large granular clonal lymphocytosis and cytopenia that emerged post-HSCT in a patient with a history of gamma delta (γδ) T-cell large granular lymphocytic leukemia (T-LGLL). Clonal unrelatedness of post-transplant T-LGL lymphocytosis to the patient's pretransplant T-LGLL was first identified by T-cell receptor (TCR) PCR showing different sized fragments of rearranged gamma chains, in addition to shift from γδ to αβ TCR expression by flow cytometry analyses. Donor-derivation of the patient's post-transplant clonal lymphocytosis was confirmed by serial chimerism analyses of recipient's blood specimens demonstrating 100% donor DNA. Moreover, oncogenic

Indexed as

Leukemia, Large Granular LymphocyticLymphocytosisClonal HematopoiesisCore Binding Factor Alpha 2 SubunitDNA Modification MethylasesHumansT-LymphocytesCore Binding Factor Alpha 2 SubunitDNA Modification MethylasesleukemiaT-cell chronic lymphocytic lymphoma/leukemiavacuolated lymphocytes

Identifiers

PMID37160316
PMCPMC10240839
OpenAlexW4376131066

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.