Evidence map›Paper›PMID 37160311›Full record

ArticleLife science alliance2023

Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish.

Byungseok Jin, Tokiro Ishikawa, Makoto Kashima, Rei Komura, Hiromi Hirata, Tetsuya Okada, Kazutoshi Mori

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Byungseok JinDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-3207-4990
Tokiro IshikawaDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0003-1718-6764
Makoto KashimaDepartment of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan.ORCID https://orcid.org/0000-0002-3953-9033
Rei KomuraDepartment of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan.
Hiromi HirataDepartment of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan.ORCID https://orcid.org/0000-0002-3769-7441
Tetsuya OkadaDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-2513-1301
Kazutoshi MoriDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan mori@upr.biophys.kyoto-u.ac.jp.ORCID https://orcid.org/0000-0001-7378-4019
Kyoto University · JPAoyama Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unfolded protein response is triggered in vertebrates by ubiquitously expressed IRE1α/β (although IRE1β is gut-specific in mice), PERK, and ATF6α/β, transmembrane-type sensor proteins in the ER, to cope with ER stress, the accumulation of unfolded and misfolded proteins in the ER. Here, we burdened medaka fish, a vertebrate model organism, with ER stress persistently from fertilization by knocking out the

Indexed as

Heart FailureOryziasX-Box Binding Protein 1Activating Transcription Factor 6Adenosine TriphosphateAnimalsEndoribonucleasesMembrane ProteinsProtein Serine-Threonine KinasesActivating Transcription Factor 6Adenosine TriphosphateEndoribonucleasesMembrane ProteinsProtein Serine-Threonine KinasesX-Box Binding Protein 1

Identifiers

PMID37160311
PMCPMC10172766
OpenAlexW4376132410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.