Evidence map›Paper›PMID 37160088›Full record

ArticleCurrent biology : CB2023

Riboswitches.

Hubert Salvail, Ronald R Breaker

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. ARNA (New York, N.Y.) · 2026
    Article
  9. RNA Triple Helices: From Structures and Mechanisms to Therapeutic Targets.International journal of biological sciences · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Human Synthetic Biology and Programmable Gene Regulation Control.Annual review of genomics and human genetics · 2025
    Review
  15. Review
  16. Article
  17. Data-driven synthetic microbes for sustainable future.NPJ systems biology and applications · 2025
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hubert SalvailDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511-8103, USA.
Ronald R BreakerDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511-8103, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511-8103, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06511-8103, USA. Electronic address: ronald.breaker@yale.edu.
Yale University · US

Funding

X-RAY ANALYSIS OF PROTEIN STRUCTURE AND FUNCTIONP01GM022778 · NIGMS · YALE UNIVERSITY · PI BREAKER, RONALD R · 1985 to 2019
$26.1M
Discovery and Characterization of New RiboswitchesR01GM136969 · NIGMS · YALE UNIVERSITY · PI STROBEL, SCOTT A · 2020 to 2023
$1.6M
Howard Hughes Medical InstituteNIGMS NIH HHS P01 GM022778
6 · The paper itself

Abstract

Riboswitches are structured noncoding RNA domains that are typically found embedded in messenger RNAs, where they sense specific target molecules or elemental ions and regulate gene expression. These RNAs thus serve as genetic switches that can activate or repress gene expression in response to changing levels of their target ligand. To many observers, riboswitches might seem like rare oddities that are not as sophisticated as, or competitive with, the various protein factors that perform these same roles. However, as the number of experimentally validated riboswitch classes increases, and their true biochemical sophistication is recognized, it is becoming clearer that many species from all three domains of life entrust RNAs to make important chemical sensing and gene control decisions without the necessary participation of protein factors.

Indexed as

RiboswitchRNARiboswitchRNA

Identifiers

PMID37160088
PMCPMC11207198
OpenAlexW4375859854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.