Evidence map›Paper›PMID 37159947›Full record

ArticleJournal of medicinal chemistry2023

Development of a Suite of Gadolinium-Free OATP1-Targeted Paramagnetic Probes for Liver MRI.

Sean W McRae, Michael Cleary, Daniel DeRoche, Francisco M Martinez, Ying Xia, Peter Caravan, Eric M Gale, John A Ronald, Timothy J Scholl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Mn-Based MRI Contrast Agents: An Overview.Molecules (Basel, Switzerland) · 2023
    Review
  8. Fe(III)Inorganic chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sean W McRaeDepartment of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.ORCID 0000-0001-8918-6144
Michael ClearyThe Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Daniel DeRocheThe Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
Francisco M MartinezImaging Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Ying XiaImaging Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Peter CaravanThe Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0002-3179-6537
Eric M GaleThe Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.ORCID 0000-0003-4567-1126
John A RonaldDepartment of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.
Timothy J SchollDepartment of Medical Biophysics, University of Western Ontario, London, Ontario N6A 3K7, Canada.ORCID 0000-0002-0807-363X
Massachusetts General Hospital · USWestern University · CAOntario Institute for Cancer Research · CA

Funding

Molecular Magnetic Resonance Imaging of InflammationR01DK120663 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Eric Michael Gale · 2019 to 2026
$4.0M
Carbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9M
Inductively Coupled Plasma Mass SpectrometerS10OD032138 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2022 to 2022
$598k
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
Noninvasive Nephritis ImagingR21DK130004 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GALE, ERIC MICHAEL · 2021 to 2022
$460k
NIDDK NIH HHS R01 DK120663NIDDK NIH HHS R21 DK130004NIH HHS S10 OD021768NIH HHS S10 OD025234NIH HHS S10 OD032138
6 · The paper itself

Abstract

Five amphiphilic, anionic Mn(II) complexes were synthesized as contrast agents targeted to organic anion transporting polypeptide transporters (OATP) for liver magnetic resonance imaging (MRI). The Mn(II) complexes are synthesized in three steps, each from the commercially available

Indexed as

LiverOrganic Anion TransportersAnimalsFemaleHumansLiver-Specific Organic Anion Transporter 1Magnetic Resonance ImagingMembrane Transport ProteinsMiceOrganic Anion Transporters, Sodium-IndependentSolute Carrier Organic Anion Transporter Family Member 1B3Liver-Specific Organic Anion Transporter 1Membrane Transport ProteinsOrganic Anion TransportersOrganic Anion Transporters, Sodium-IndependentSolute Carrier Organic Anion Transporter Family Member 1B3

Identifiers

PMID37159947
PMCPMC12074583
OpenAlexW4376106594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.