Observational studyThe Journal of clinical endocrinology and metabolism2023
Gut Microbiota Composition and Functionality Are Associated With REM Sleep Duration and Continuous Glucose Levels.
Observational study in The Journal of clinical endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What is the nature of sleep and circadian rhythm health on gastrointestinal microbiota? A systematic review of studies in humans.Sleep medicine reviews · 2026Pooled it
- Subjective and objective sleep quality during late pregnancy and the association with maternal gut microbiota in Chinese pregnant women.Sleep & breathing = Schlaf & Atmung · 2026Article
- Longitudinal sleep duration trajectories and their association with cardio-renal-metabolic multimorbidity risk in postmenopausal women: evidence from the CHARLS study.BMC public health · 2026Article
- From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I).Neuroscience and biobehavioral reviews · 2026Review
- Life's Essential 8, phenotypic age, and cardiovascular age in prediabetes: predictive value in the UK Biobank and protein mediation in cardiovascular-diabetes comorbidity.European journal of medical research · 2025Article
- Defining Continuous Glucose Monitor Time in Range in a Large, Community-Based Cohort Without Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- The Effect of Sleep Disruption on Cardiometabolic Health.Life (Basel, Switzerland) · 2025Review
- Identification of gut microbiome features associated with host metabolic health in a large population-based cohort.Nature communications · 2024Article
- Soluble receptors for advanced glycation endproducts are predictors of insulin sensitivity and affected by weight loss.Nutrition & diabetes · 2024Article
- Article
- Habitual Short Sleep Duration, Diet, and Development of Type 2 Diabetes in Adults.JAMA network open · 2024Article
- Sleep duration and its association with constipation in patients with diabetes: The fukuoka diabetes registry.PloS one · 2024Article
- Effect of Preoperative Level of Glycemic Control with Pulsed Radiofrequency on the Incidence of Postherpetic Neuralgia in Patients with Herpes Zoster Combined with Type 2 Diabetes Mellitus: A Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Sweet Dreams for Better Metabolic Health.The Journal of clinical endocrinology and metabolism · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextSleep disruption is associated with worse glucose metabolic control and altered gut microbiota in animal models.
objectiveWe aimed to evaluate the possible links among rapid eye movement (REM) sleep duration, continuous glucose levels, and gut microbiota composition.
methodsThis observational, prospective, real-life, cross-sectional case-control study included 118 (60 with obesity), middle-aged (39.1-54.8 years) healthy volunteers recruited at a tertiary hospital. Glucose variability and REM sleep duration were assessed by 10-day continuous glucose monitoring (CGM) (Dexcom G6) and wrist actigraphy (Fitbit Charge 3), respectively. The coefficient of variation (CV), interquartile range (IQR), and SD of glucose variability was assessed and the percentage of time in range (% TIR), at 126-139 mg/dL (TIR2), and 140-199 mg/dL (TIR3) were calculated. Shotgun metagenomics sequencing was applied to study gut microbiota taxonomy and functionality.
resultsIncreased glycemic variability (SD, CV, and IQR) was observed among subjects with obesity in parallel to increased % TIR2 and % TIR3. REM sleep duration was independently associated with % TIR3 (β = -.339; P < .001) and glucose variability (SD, β = -.350; P < .001). Microbial taxa from the Christensenellaceae family (Firmicutes phylum) were positively associated with REM sleep and negatively with CGM levels, while bacteria from Enterobacteriacea family and bacterial functions involved in iron metabolism showed opposite associations.
conclusionDecreased REM sleep duration was independently associated with a worse glucose profile. The associations of species from Christensenellaceae and Enterobacteriaceae families with REM sleep duration and continuous glucose values suggest an integrated picture of metabolic health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.