Evidence map›Paper›PMID 37159501›Full record

ArticleeLife2023

PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner.

Hanghang Liu, Akane Wada, Isabella Le, Phuong T Le, Andrew W F Lee, Jun Zhou, Francesca Gori, Roland Baron, Clifford J Rosen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The role of bone in whole-body energy metabolism.Nature reviews. Endocrinology · 2025
    Review
  5. Review
  6. PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth.International journal of molecular sciences · 2024
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Hanghang LiuMaine Medical Center Research Institute, Maine Medical Center, Scarborough, United States.
Akane WadaDivision of Bone and Mineral Research, Dept of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, United States.
Isabella LeMaine Medical Center Research Institute, Maine Medical Center, Scarborough, United States.
Phuong T LeMaine Medical Center Research Institute, Maine Medical Center, Scarborough, United States.
Andrew W F LeeMaine Medical Center Research Institute, Maine Medical Center, Scarborough, United States.
Jun ZhouDivision of Bone and Mineral Research, Dept of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, United States.
Francesca GoriDivision of Bone and Mineral Research, Dept of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, United States.ORCID 0000-0001-5685-8303
Roland BaronDivision of Bone and Mineral Research, Dept of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, United States.
Clifford J RosenMaine Medical Center Research Institute, Maine Medical Center, Scarborough, United States.ORCID 0000-0003-3436-8199
Harvard University · USMaine Medical Center Research Institute · USBoston University · USNew England College · USSichuan University · CN

Funding

Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
Mechanism of action of PTH: New signaling components that regulate bone formation and bone marrow fatR01AR073774 · NIAMS · HARVARD MEDICAL SCHOOL · PI BARON, ROLAND E, ROSEN, CLIFFORD JAMES · 2020 to 2024
$2.8M
PTH resistance and marrow adipogenesisR01DK112374 · NIDDK · HARVARD MEDICAL SCHOOL · PI BARON, ROLAND E, ROSEN, CLIFFORD JAMES · 2017 to 2020
$2.2M
Mechanisms by which adipocytes adapt to cool environmental temperaturesR01DK121759 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MACDOUGALD, ORMOND A · 2020 to 2024
$2.0M
PTH resistance and marrow adipogenesisR56DK112374 · NIDDK · HARVARD MEDICAL SCHOOL · PI MANNSTADT, BEATE, ROSEN, CLIFFORD JAMES · 2016 to 2016
$85k
NIAMS NIH HHS R01 AR073774NIDDK NIH HHS R01 DK112374NIDDK NIH HHS R01 DK121759NIDDK NIH HHS R24 DK092759NIDDK NIH HHS R56 DK112374
6 · The paper itself

Abstract

Conditional deletion of the PTH1R in mesenchymal progenitors reduces osteoblast differentiation, enhances marrow adipogenesis, and increases zinc finger protein 467 (

Indexed as

AdipogenesisOsteogenesisAnimalsCell DifferentiationCyclic AMPMiceOsteoblastsParathyroid HormoneReceptor, Parathyroid Hormone, Type 1Cyclic AMPParathyroid HormonePTH1R protein, mousePth protein, mouseReceptor, Parathyroid Hormone, Type 1cell biologymouseosteogenesisPKA pathwayPTHPTH receptorregenerative medicinestem cellszinc finger protein 467

Identifiers

PMID37159501
PMCPMC10171860
OpenAlexW4367050745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.