Evidence map›Paper›PMID 37158942›Full record

ArticleBMC medicine2023

Early sex-dependent differences in metabolic profiles of overweight and adiposity in young children: a cross-sectional analysis.

Sandi M Azab, Meera Shanmuganathan, Russell J de Souza, Zachary Kroezen, Dipika Desai, Natalie C Williams, Katherine M Morrison, Stephanie A Atkinson, Koon K Teo, Meghan B Azad and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. From Fetus to Eight: the CHILD Cohort Study.American journal of epidemiology · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Sandi M AzabDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Meera ShanmuganathanDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Russell J de SouzaChanchlani Research Centre, McMaster University, Hamilton, Canada.
Zachary KroezenDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Dipika DesaiDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Natalie C WilliamsDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Katherine M MorrisonPopulation Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada.
Stephanie A AtkinsonDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Koon K TeoDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Meghan B AzadDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Elinor SimonsDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Theo J MoraesDepartment of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.
Piush J MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Stuart E TurveyDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
Padmaja SubbaraoDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Philip Britz-McKibbinDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
Sonia S AnandDepartment of Medicine, McMaster University, Hamilton, ON, Canada. anands@mcmaster.ca.ORCID 0000-0003-3692-7441
McMaster University · CAMcMaster University Medical Centre · CAPopulation Health Research Institute · CAChildren's Hospital Research Institute of Manitoba · CAHospital for Sick Children · CAUniversity of Alberta · CAUniversity of British Columbia · CA

Funding

Canadian Institutes for Health Research MWG-146332
6 · The paper itself

Abstract

backgroundChildhood obesity is a global health concern and can lead to lifetime cardiometabolic disease. New advances in metabolomics can provide biochemical insights into the early development of obesity, so we aimed to characterize serum metabolites associated with overweight and adiposity in early childhood and to stratify associations by sex.

methodsNontargeted metabolite profiling was conducted in the Canadian CHILD birth cohort (discovery cohort) at age 5 years (n = 900) by multisegment injection-capillary electrophoresis-mass spectrometry. Clinical outcome was defined using novel combined measures of overweight (WHO-standardized body mass index ≥ 85th percentile) and/or adiposity (waist circumference ≥ 90th percentile). Associations between circulating metabolites and child overweight/adiposity (binary and continuous outcomes) were determined by multivariable linear and logistic regression, adjusting for covariates and false discovery rate, and by subsequent sex-stratified analysis. Replication was assessed in an independent replication cohort called FAMILY at age 5 years (n = 456).

resultsIn the discovery cohort, each standard deviation (SD) increment of branched-chain and aromatic amino acids, glutamic acid, threonine, and oxoproline was associated with 20-28% increased odds of overweight/adiposity, whereas each SD increment of the glutamine/glutamic acid ratio was associated with 20% decreased odds. All associations were significant in females but not in males in sex-stratified analyses, except for oxoproline that was not significant in either subgroup. Similar outcomes were confirmed in the replication cohort, where associations of aromatic amino acids, leucine, glutamic acid, and the glutamine/glutamic acid ratio with childhood overweight/adiposity were independently replicated.

conclusionsOur findings show the utility of combining measures of both overweight and adiposity in young children. Childhood overweight/adiposity at age 5 years has a specific serum metabolic phenotype, with the profile being more prominent in females compared to males.

Indexed as

OverweightPediatric ObesityAdiposityAmino Acids, AromaticCanadaChildChild, PreschoolCross-Sectional StudiesFemaleGlutamatesGlutamineHumansMaleMetabolomeAmino Acids, AromaticGlutamatesGlutamineAromatic amino acidsChildhood adiposityChildhood overweightSerum metabolomicsSex differencesWaist circumference

Identifiers

PMID37158942
PMCPMC10166631
OpenAlexW4375955363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.