Evidence map›Paper›PMID 37158590›Full record

ArticleeLife2023

Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes.

Benjamin M Zemel, Alexander A Nevue, Leonardo E S Tavares, Andre Dagostin, Peter V Lovell, Dezhe Z Jin, Claudio V Mello, Henrique von Gersdorff

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Gene regulatory co-option drives birdsong neural circuit specialization.bioRxiv : the preprint server for biology · 2026
    Article
  2. Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Benjamin M ZemelVollum Institute, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-6701-0647
Alexander A NevueDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, United States.
Leonardo E S TavaresVollum Institute, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-8642-5186
Andre DagostinVollum Institute, Oregon Health and Science University, Portland, United States.
Peter V LovellDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, United States.
Dezhe Z JinDepartment of Physics, Pennsylvania State University, University Park, United States.
Claudio V MelloDepartment of Behavioral Neuroscience, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-9826-8421
Henrique von GersdorffVollum Institute, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-4404-3307
Oregon Health & Science University · USPennsylvania State University · US

Funding

PRESERVATION OF TIMING IN PLASTIC AUDITORY PATHWAYSR01DC004274 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI VON GERSDORFF, HENRIQUE PRADO · 2000 to 2021
$6.6M
Modulation of Exocytosis and Excitability in Mature Auditory Brainstem NeuronsR01DC012938 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI VON GERSDORFF, HENRIQUE PRADO · 2013 to 2024
$5.1M
Neuroscience of Aging, Neurodegeneration and Alzheimer’s DiseaseT32AG055378 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOB RABER, HENRYK F URBANSKI · 2018 to 2026
$4.3M
Transition Support for ZEBrA, A Gene Expression Brain Atlas of the Zebra FinchR24GM120464 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MELLO, CLAUDIO V · 2016 to 2018
$403k
NIA NIH HHS T32 AG055378NIDCD NIH HHS R01 DC004274NIDCD NIH HHS R01 DC012938NIGMS NIH HHS R24 GM120464
6 · The paper itself

Abstract

Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels involved, we conducted a thorough study of the excitability of upper motor neurons controlling somatic motor function in the zebra finch. We found that robustus arcopallialis projection neurons (RAPNs), key command neurons for song production, exhibit ultranarrow spikes and higher firing rates compared to neurons controlling non-vocal somatic motor functions (dorsal intermediate arcopallium [AId] neurons). Pharmacological and molecular data indicate that this striking difference is associated with the higher expression in RAPNs of high threshold, fast-activating voltage-gated Kv3 channels, that likely contain Kv3.1 (

Indexed as

Motor CortexPotassium Channels, Voltage-GatedSongbirdsAction PotentialsAnimalsInterneuronsMotor NeuronsShaw Potassium ChannelsPotassium Channels, Voltage-GatedShaw Potassium Channelsaction potentialexcitabilityneurosciencepatch-clamp electrophysiologypotassium channelsvocal/motor cortexzebra finch

Identifiers

PMID37158590
PMCPMC10241522
OpenAlexW4375955323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.