Evidence map›Paper›PMID 37158562›Full record

ArticleEMBO reports2023

Energetic landscape of polycystin channel gating.

Leo Ct Ng, Brandon J Harris, Megan Larmore, My C Ta, Thuy N Vien, Valerie L Tokars, Vladimir Yarov-Yarovoy, Paul G DeCaen

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Leo Ct NgDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-0492-5460
Brandon J HarrisDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-3894-0180
Megan LarmoreDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
My C TaDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Thuy N VienDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Valerie L TokarsDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-2619-3969
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-2325-4834
Paul G DeCaenDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-8776-983X
Northwestern University · USUniversity of California, Davis · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
Training Core for Chicago KUH FORWARDTL1DK132769 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Tamara Isakova · 2021 to 2026
$4.0M
Molecular dysregulation of primary cilia TRPP2 channels caused by Finger 1 variantsR01DK123463 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DECAEN, PAUL GREGORY · 2019 to 2023
$2.0M
Cilia calcium dysregulation in polycystic kidney diseaseR01DK131118 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Paul Gregory DeCaen · 2022 to 2026
$1.9M
The mechanistic impact of Finger 1 variants on polycystin-2 (PKD2) channels in the primary ciliaR56DK119709 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DECAEN, PAUL GREGORY · 2018 to 2018
$138k
NCI NIH HHS P30 CA060553NIDDK NIH HHS R01 DK123463NIDDK NIH HHS R01 DK131118NIDDK NIH HHS R56 DK119709NIDDK NIH HHS TL1 DK132769NIGMS NIH HHS T32 GM007377NIGMS NIH HHS T32 GM008382
6 · The paper itself

Abstract

Members of the polycystin family (PKD2 and PKD2L1) of transient receptor potential (TRP) channels conduct Ca

Indexed as

Transient Receptor Potential ChannelsTRPP Cation ChannelsAnimalsCalcium ChannelsHumansIon TransportMiceMutationReceptors, Cell SurfaceSignal TransductionCalcium ChannelsPKD2L1 protein, humanReceptors, Cell SurfaceTransient Receptor Potential ChannelsTRPP Cation Channelscalciumpolycystic kidney diseasepolycystinsstructural biologyTRP channels

Identifiers

PMID37158562
PMCPMC10328073
OpenAlexW4375955486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.