ReviewEFORT open reviews2023
Biological aspects to enhance fracture healing.
Review in EFORT open reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Prospective Evaluation of Functional Outcomes in Schatzker Type V-VI Proximal Tibia Fractures Managed with Locking Compression Plate Using Minimally Invasive Percutaneous Plate Osteosynthesis.Journal of orthopaedic case reports · 2026Article
- Radiological Outcomes of Reamed Short Proximal Femoral Nailing in Intertrochanteric Fractures in Patients Aged 50 Years and Above.Journal of orthopaedic case reports · 2026Article
- Initial fracture gap distance as a potential quantitative predictor for atlas fracture nonunion: A preliminary retrospective analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Atrophic Long-Bone Non-Union: Current Insights into Pathogenesis and Management-A Narrative Review.Journal of clinical medicine · 2026Review
- Global shoulder instability in a seizure patient: anterior and posterior glenoid reconstruction with humeral head reconstruction. A case report.JSES reviews, reports, and techniques · 2026Article
- Safety and Efficacy of rhBMP-2 for Treating Acute Traumatic Fractures of the Upper and Lower Extremities: A Multicenter Prospective Study.Journal of clinical medicine · 2026Article
- Reconstruction of complex foot injury using anterior thigh free flap with vastus lateralis muscle pedicle and tri-cortical Iliac crest bone graft: a case report.Annals of medicine and surgery (2012) · 2025Article
- Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation.NPJ Regenerative medicine · 2025Article
- Bone void filler materials for augmentation in comminuted fractures: a comprehensive review.Journal of orthopaedic surgery and research · 2025Review
- Distal femoral bone defect treatment using an engineered hydroxyapatite cylinder scaffold made from rattan wood.BMJ case reports · 2025Article
- Dual release scaffolds as a promising strategy for enhancing bone regeneration: an updated review.Nanomedicine (London, England) · 2025Review
- Application of collagen in bone regeneration.Journal of orthopaedic translation · 2025Review
- The predictive value of stress-induced hyperglycemia parameters for delayed healing after tibial fracture post-surgery.Journal of orthopaedic surgery and research · 2024Article
- Cellular therapies for bone repair: current insights.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2024Review
- A parathyroid hormone related supramolecular peptide for multi-functionalized osteoregeneration.Bioactive materials · 2024Article
- Fracture healing on non-union fracture model promoted by non-thermal atmospheric-pressure plasma.PloS one · 2024Article
- Enhancing bone tissue engineering with 3D-Printed polycaprolactone scaffolds integrated with tragacanth gum/bioactive glass.Materials today. Bio · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to enhance fracture healing is paramount in modern orthopaedic trauma, particularly in the management of challenging cases including peri-prosthetic fractures, non-union and acute bone loss. Materials utilised in enhancing fracture healing should ideally be osteogenic, osteoinductive, osteoconductive, and facilitate vascular in-growth. Autologous bone graft remains the gold standard, providing all of these qualities. Limitations to this technique include low graft volume and donor site morbidity, with alternative techniques including the use of allograft or xenograft. Artificial scaffolds can provide an osteoconductive construct, however fail to provide an osteoinductive stimulus, and frequently have poor mechanical properties. Recombinant bone morphogenetic proteins can provide an osteoinductive stimulus; however, their licencing is limited and larger studies are required to clarify their role. For recalcitricant non-unions or high-risk cases, the use of composite graft combining the above techniques provides the highest chances of successfully achieving bony union.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.