Evidence map›Paper›PMID 37158173›Full record

ArticleSleep2023

Feeling sleepy? stop driving-awareness of fall asleep crashes.

Clare Anderson, Anna W T Cai, Michael L Lee, William J Horrey, Yulan Liang, Conor S O'Brien, Charles A Czeisler, Mark E Howard

Open access · hybridAbstract read
In one paragraph

Article in Sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The role of microsleeps to estimate sleepiness at the wheel and near-miss accidents in obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Clare AndersonTurner Institute of Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-5086-4865
Anna W T CaiTurner Institute of Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-5604-2902
Michael L LeeDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-3112-1214
William J HorreyCenter for Behavioral Sciences, Liberty Mutual Research Institute for Safety, Hopkinton, MA, USA.ORCID 0000-0002-9533-4411
Yulan LiangCenter for Behavioral Sciences, Liberty Mutual Research Institute for Safety, Hopkinton, MA, USA.
Conor S O'BrienDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Charles A CzeislerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Mark E HowardTurner Institute of Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.ORCID 0000-0001-7772-1496
Brigham and Women's Hospital · USAAA Foundation for Traffic Safety · USLiberty Mutual Research Institute for Safety · USMonash University · AU

Funding

TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety-CCCU01HL111478 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A, LANDRIGAN, CHRISTOPHER PAUL · 2012 to 2017
$8.4M
Treatment of Circadian Disruption from Shiftwork in Older AdultsR01AG044416 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI DUFFY, JEANNE F · 2013 to 2022
$4.3M
NHLBI NIH HHS T32 HL007901NHLBI NIH HHS U01 HL111478NHLBI NIH HHS U01-HL111478NIA NIH HHS R01 AG044416NIA NIH HHS R01-AG044416NIH HHS 5T32HL7901-14
6 · The paper itself

Abstract

STUDY

objectivesTo examine whether drivers are aware of sleepiness and associated symptoms, and how subjective reports predict driving impairment and physiological drowsiness.

methodsSixteen shift workers (19-65 years; 9 women) drove an instrumented vehicle for 2 hours on a closed-loop track after a night of sleep and a night of work. Subjective sleepiness/symptoms were rated every 15 minutes. Severe and moderate driving impairment was defined by emergency brake maneuvers and lane deviations, respectively. Physiological drowsiness was defined by eye closures (Johns drowsiness scores) and EEG-based microsleep events.

resultsAll subjective ratings increased post night-shift (p < 0.001). No severe drive events occurred without noticeable symptoms beforehand. All subjective sleepiness ratings, and specific symptoms, predicted a severe (emergency brake) driving event occurring in the next 15 minutes (OR: 1.76-2.4, AUC > 0.81, p < 0.009), except "head dropping down". Karolinska Sleepiness Scale (KSS), ocular symptoms, difficulty keeping to center of the road, and nodding off to sleep, were associated with a lane deviation in the next 15 minutes (OR: 1.17-1.24, p<0.029), although accuracy was only "fair" (AUC 0.59-0.65). All sleepiness ratings predicted severe ocular-based drowsiness (OR: 1.30-2.81, p < 0.001), with very good-to-excellent accuracy (AUC > 0.8), while moderate ocular-based drowsiness was predicted with fair-to-good accuracy (AUC > 0.62). KSS, likelihood of falling asleep, ocular symptoms, and "nodding off" predicted microsleep events, with fair-to-good accuracy (AUC 0.65-0.73).

conclusionsDrivers are aware of sleepiness, and many self-reported sleepiness symptoms predicted subsequent driving impairment/physiological drowsiness. Drivers should self-assess a wide range of sleepiness symptoms and stop driving when these occur to reduce the escalating risk of road crashes due to drowsiness.

Indexed as

Accidents, TrafficAutomobile DrivingFemaleHumansSleepSleepinessWakefulnessdrivingDrowsinesseye closurelane departuresleepinesssubjective

Identifiers

PMID37158173
PMCPMC10636256
OpenAlexW4375954796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.