Evidence map›Paper›PMID 37158118›Full record

ArticleJournal of the American Heart Association2023

Clinical Profile, Health Care Costs, and Outcomes of Patients Hospitalized for Heart Failure With Severely Reduced Ejection Fraction.

Josephine Harrington, Jie-Lena Sun, Gregg C Fonarow, Stephen B Heitner, Punag H Divanji, Gary Binder, Larry A Allen, Brooke Alhanti, Clyde W Yancy, Nancy M Albert and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Observational
  3. Observational
  4. Global & regional health technology assessment
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Josephine HarringtonDivision of Cardiology Duke University School of Medicine Durham NC.ORCID 0000-0001-5169-117X
Jie-Lena SunDuke Clinical Research Institute Durham NC USA.ORCID 0000-0002-4453-9441
Gregg C FonarowDivision of Cardiology, Ahmanson-UCLA Cardiomyopathy Center University of California Los Angeles Medical Center Los Angeles CA.ORCID 0000-0002-3192-8093
Stephen B HeitnerCytokinetics South San Francisco CA.ORCID 0000-0003-2189-1474
Punag H DivanjiCytokinetics South San Francisco CA.
Gary BinderCytokinetics South San Francisco CA.
Larry A AllenDivision of Cardiology & Colorado Cardiovascular Outcomes Research Consortium University of Colorado School of Medicine Aurora CO.ORCID 0000-0003-2540-3095
Brooke AlhantiDuke Clinical Research Institute Durham NC USA.ORCID 0000-0003-4243-8062
Clyde W YancyDivision of Cardiology Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0001-7271-4166
Nancy M AlbertNursing Institute and Kaufman Center for Heart Failure Cleveland Clinic Cleveland OH.ORCID 0000-0002-3619-966X
Adam D DeVoreDivision of Cardiology Duke University School of Medicine Durham NC.ORCID 0000-0002-4679-2221
G Michael FelkerDivision of Cardiology Duke University School of Medicine Durham NC.ORCID 0000-0002-5931-1239
Stephen J GreeneDivision of Cardiology Duke University School of Medicine Durham NC.ORCID 0000-0001-6912-7374
Duke University · USCytokinetics (United States) · USClinical Research Institute · USCleveland Clinic · USNorthwestern University · USOutcomes Research Consortium · USUniversity of California, Los Angeles · US

Funding

Postdoctoral Training in Cardiovascular Clinical ResearchT32HL069749 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2003 to 2023
$6.7M
NHLBI NIH HHS T32 HL069749
6 · The paper itself

Abstract

Background Many patients with heart failure (HF) have severely reduced ejection fraction but do not meet threshold for consideration of advanced therapies (ie, stage D HF). The clinical profile and health care costs associated with these patients in US practice is not well described. Methods and Results We examined patients hospitalized for worsening chronic heart failure with reduced ejection fraction ≤40% from 2014 to 2019 in the GWTG-HF (Get With The Guidelines-Heart Failure) registry, who did not receive advanced HF therapies or have end-stage kidney disease. Patients with severely reduced EF defined as EF ≤30% were compared with those with EF 31% to 40% in terms of clinical profile and guideline-directed medical therapy. Among Medicare beneficiaries, postdischarge outcomes and health care expenditure were compared. Among 113 348 patients with EF ≤40%, 69% (78 589) had an EF ≤30%. Patients with severely reduced EF ≤30% tended to be younger and were more likely to be Black. Patients with EF ≤30% also tended to have fewer comorbidities and were more likely to be prescribed guideline-directed medical therapy ("triple therapy" 28.3% versus 18.2%,

Indexed as

AftercareHeart FailureAgedHealth Care CostsHospitalizationHumansMedicarePatient DischargeStroke VolumeUnited Statescostsejection fractionheart failureoutcomes

Identifiers

PMID37158118
PMCPMC10227282
OpenAlexW4375955390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.