ArticleCirculation. Cardiovascular imaging2023
Atrial Dysfunction in Significant Atrial Functional Mitral Regurgitation: Phenotypes and Prognostic Implications.
Article in Circulation. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Prevalence and prognostic implications of chronic kidney disease in patients with atrial functional mitral regurgitation.International journal of cardiology. Heart & vasculature · 2026Article
- Optimal surgical timing for atrial functional mitral regurgitation based on preoperative diuretic requirement: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Stress-Induced Reversible Left Atrial and Mitral Annular Dilation Causing Severe Transient Central Mitral Regurgitation: First Reported Case.Circulation. Cardiovascular imaging · 2026Article
- Prognostic implications of impaired three-dimensional left atrial function and stiffness in primary mitral regurgitation.Cardiovascular ultrasound · 2026Article
- Prognostic value of left atrial reservoir strain and global work efficiency in medically managed secondary mitral regurgitation: a mediation analysis.Frontiers in cardiovascular medicine · 2026Article
- Epidemiology, pathophysiology, diagnosis and management of atrial functional mitral regurgitation: An expert opinion paper.ESC heart failure · 2025Review
- Outcomes of Mitral Valve Surgery for Atrial Functional Mitral Regurgitation vs Ventricular Functional Mitral Regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Mitral annular remodelling after STEMI is associated with new-onset dilatation of the left cardiac chambers and impaired left atrial function.European heart journal. Imaging methods and practice · 2025Article
- Association of Left Atrial Function With Mitral Regurgitation: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2025Observational
- Atrial functional mitral regurgitation: definition, features, and unknowns.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Review
- Left atrial dysfunction relates to symptom onset in patients affected by severe degenerative mitral regurgitation.Cardiovascular ultrasound · 2024Article
- Pulmonary hypertension associated with left heart disease.The European respiratory journal · 2024Review
- Atrial Functional Mitral Regurgitation: From Diagnosis to Current Interventional Therapies.Journal of clinical medicine · 2024Review
- Sex differences in left atrial volumes, mechanics, and stiffness in primary mitral regurgitation-a combined 2D and 3D echocardiographic study.European heart journal. Cardiovascular Imaging · 2024Observational
- Imaging for the assessment of the arrhythmogenic potential of mitral valve prolapse.European radiology · 2024Review
- Distinct leaflet-annular remodeling pattern in severe atrial functional mitral regurgitation: a three-dimensional echocardiography study.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2024Article
- Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults.JACC. Advances · 2024Article
- Left Atrium: A New Prognostic Marker and Therapeutic Target in Secondary Mitral Regurgitation?European cardiology · 2024Review
- Impact of Percutaneous Mitral Valve Repair on Left Atrial Strain and Atrial Fibrillation Progression.Journal of cardiovascular development and disease · 2023Article
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
backgroundAtrial functional mitral regurgitation (AFMR) is associated with increased morbidity and mortality. Left atrial (LA) size and function in AFMR are poorly characterized. We aimed to assess LA function by reservoir strain (LASr) and estimated reservoir work (LAWr) and their impact on outcome in AFMR.
methodsConsecutive patients at our institution between 2001 and 2019 and with significant (moderate or greater) AFMR were examined. LAWr was estimated as LASr×LA reservoir volume, and patients were grouped by median LASr and LAWr. Outcomes were all-cause death or heart failure hospitalizations.
resultsFive hundred fifteen AFMR patients were followed up for 5 (1-17) years. Patients had previously documented atrial fibrillation (AF; 37%), heart failure with preserved ejection fraction (HFpEF) without AF (24%), or both (HFpEF+AF, 39%). LA volume was largest in AF, while LA function parameters were most impaired in the combined HFpEF+AF group. During follow-up, patients with low LASr or LAWr had higher risk of death (
conclusionsLA reservoir function but not LA size is a robust predictor of outcome in significant AFMR. This provides mechanistic insights into the interplay of functional versus geometric LA changes in AFMR.
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