Evidence map›Paper›PMID 37157206›Full record

ReviewCurrent drug research reviews2024

Ligand- and Structure-based Approaches for Transmembrane Transporter Modeling.

Melanie Grandits, Gerhard F Ecker

Abstract readReview
In one paragraph

Review in Current drug research reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melanie GranditsDepartment of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.ORCID 0000-0002-8955-1989
Gerhard F EckerDepartment of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.ORCID 0000-0003-4209-6883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of transporter proteins is key to understanding the mechanism behind multidrug resistance and drug-drug interactions causing severe side effects. While ATP-binding transporters are well-studied, solute carriers illustrate an understudied family with a high number of orphan proteins. To study these transporters,

Indexed as

Membrane Transport ProteinsComputer SimulationDrug DiscoveryHumansLigandsMachine LearningModels, MolecularLigandsMembrane Transport ProteinsABC transporter(s)breast cancer resistance protein (BCRP)in silico modelingmachine learningP-glycoprotein (P-gp)quantitative structure-activity relationship(s) (QSAR)solute carrier (SLC) transporter(s).

Identifiers

PMID37157206
PMCPMC11340286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.