Evidence map›Paper›PMID 37157007›Full record

ReviewClinical rheumatology2023

Lupus anti-coagulant hypoprothrombinemia syndrome across different ages: a case report and review of the literature.

Jessica Chumsky, Philip J Kahn, William L Carroll, Kristyn A Pierce, Kirsty Hillier

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Clinical rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jessica ChumskyDepartment of Pediatrics, NYU Langone Health, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8983-6829
Philip J KahnDepartment of Pediatrics, Division of Pediatric Rheumatology, Hassenfeld Children's Hospital at NYU Langone Health, NYU Grossman School of Medicine, New York, NY, USA.
William L CarrollPerlmutter Cancer Center, Departments of Pediatrics and Pathology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1550-4167
Kristyn A PierceDepartment of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, NYU Grossman School of Medicine, New York, NY, USA.
Kirsty HillierDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Hassenfeld Children's Hospital at NYU Langone Health, NYU Grossman School of Medicine, 160 E 32Nd St., L3 Medical, New York, NY, 10016, USA. Kirsty.hillier@nyulangone.org.ORCID http://orcid.org/0000-0001-7080-2293
NYU Langone Health · USNYU Langone’s Laura and Isaac Perlmutter Cancer Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lupus anti-coagulant hypoprothrombinemia syndrome (LAHPS) is a rare condition that can be difficult to treat. It increases the risk of thrombosis and bleeding due to the presence of lupus anti-coagulant and factor II deficiency, respectively. There are a limited number of cases described in the literature. Herein we describe a case of LAHPS with bleeding symptoms as a first clinical manifestation of systemic lupus erythematosus (SLE) in an 8-year-old female. She has had multiple recurrences of her bleeding symptoms, requiring treatment with steroids, cyclophosphamide, mycophenolate mofetil, and rituximab. Her course was later complicated by development of arthritis and lupus nephritis. Her complicated course provides a new perspective on the clinical course and treatment of LAHPS. We also present a comprehensive literature review which demonstrates the difficulty in treating patients with LAHPS with underlying SLE and the variability of the clinical course and management of LAHPS depending on the age at presentation.

Indexed as

HypoprothrombinemiasLupus Erythematosus, SystemicChildCyclophosphamideDisease ProgressionFemaleHemorrhageHumansLupus Coagulation InhibitorCyclophosphamideLupus Coagulation InhibitorAnti-phospholipid syndromeBleedingSystemic lupus erythematosusThromboses

Identifiers

PMID37157007
OpenAlexW4375859170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.