ArticleCommunications biology2023
Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape.
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Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13citing papers in PubMed, 1 pooled it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective.Human molecular genetics · 2025Pooled it
- The craniofacial shape of modern humans embodies genomic signatures of evolution, diversity, and clinical conditions.bioRxiv : the preprint server for biology · 2026Article
- Genetic ancestry influences body shape and obesity risk in Latin American populations.Scientific reports · 2025Article
- Archaic adaptive introgression in modern human reproductive genes.Communications biology · 2025Article
- Association ofInternational journal of molecular sciences · 2025Article
- Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction.Nature communications · 2025Article
- Enhanced insights into the genetic architecture of 3D cranial vault shape using pleiotropy-informed GWAS.Communications biology · 2025Article
- Optimized phenotyping of complex morphological traits: enhancing discovery of common and rare genetic variants.Briefings in bioinformatics · 2025Article
- Archaic hominin admixture and its consequences for modern humans.Current opinion in genetics & development · 2025Review
- PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans.Current biology : CB · 2025Article
- Mapping genes for human face shape: Exploration of univariate phenotyping strategies.PLoS computational biology · 2024Article
- Population diversity and equity in the genomic era: going global to return to the local.Journal of community genetics · 2023Review
- Neanderthal introgression in SCN9A impacts mechanical pain sensitivity.Communications biology · 2023Article
Corrections and comments
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Authors and funding
39 authors at 17 institutions in 11 countries.
Qing Li *Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, 200438, China.ORCID 0009-0000-5172-5755
Jieyi Chen *Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, 200438, China.
Pierre FauxAix-Marseille Université, CNRS, EFS, ADES, Marseille, 13005, France.ORCID 0000-0003-4486-6327
Miguel Eduardo DelgadoMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, 200438, China.
Betty BonfanteAix-Marseille Université, CNRS, EFS, ADES, Marseille, 13005, France.
Macarena Fuentes-GuajardoDepartamento de Tecnología Médica, Facultad de Ciencias de la Salud, Universidad de Tarapacá, Arica, 1000000, Chile.
Javier Mendoza-RevillaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú.
J Camilo Chacón-DuqueDivision of Vertebrates and Anthropology, Department of Earth Sciences, Natural History Museum, London, SW7 5BD, UK.ORCID 0000-0003-0715-1947
Malena HurtadoLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú.
Valeria VillegasLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú.
Vanessa GranjaLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú.
Claudia JaramilloGENMOL (Genética Molecular), Universidad de Antioquia, Medellín, 5001000, Colombia.
William AriasGENMOL (Genética Molecular), Universidad de Antioquia, Medellín, 5001000, Colombia.ORCID 0000-0002-2543-4855
Rodrigo BarqueraMolecular Genetics Laboratory, National School of Anthropology and History, Mexico City, 14050, Mexico, 6600, Mexico.ORCID 0000-0003-0518-4518
Paola Everardo-MartínezMolecular Genetics Laboratory, National School of Anthropology and History, Mexico City, 14050, Mexico, 6600, Mexico.
Mirsha Sánchez-QuintoForensic Science, Faculty of Medicine, UNAM (Universidad Nacional Autónoma de México), Mexico City, 06320, Mexico.
Jorge Gómez-ValdésMolecular Genetics Laboratory, National School of Anthropology and History, Mexico City, 14050, Mexico, 6600, Mexico.ORCID 0000-0001-6996-2732
Hugo Villamil-RamírezUnidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica, Mexico City, 4510, Mexico.
Caio C Silva de CerqueiraScientific Police of São Paulo State, Ourinhos, SP, 19900-109, Brazil.
Tábita HünemeierDepartamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, 05508-090, Brazil.
Virginia RamalloDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90040-060, Brazil.
Sijie WuMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, 200438, China.
Siyuan DuCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China.ORCID 0000-0003-1602-1669
Andrea GiardinaSchool of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, United Kingdom.ORCID 0000-0003-3409-8053
Soumya Subhra PariaSchool of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, United Kingdom.
Mahfuzur Rahman KhokanSchool of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, United Kingdom.
Rolando Gonzalez-JoséInstituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn, U9129ACD, Argentina.
Lavinia Schüler-FacciniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90040-060, Brazil.
Maria-Cátira BortoliniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90040-060, Brazil.
Victor Acuña-AlonzoMolecular Genetics Laboratory, National School of Anthropology and History, Mexico City, 14050, Mexico, 6600, Mexico.
Samuel Canizales-QuinterosUnidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica, Mexico City, 4510, Mexico.
Carla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú.
Giovanni PolettiLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, 31, Perú.
Winston RojasGENMOL (Genética Molecular), Universidad de Antioquia, Medellín, 5001000, Colombia.
Francisco RothhammerInstituto de Alta Investigación, Universidad de Tarapacá, Arica, Arica, 1000000, Chile.
Nicolas NavarroBiogéosciences, UMR 6282 CNRS, Université de Bourgogne, Dijon, 21000, France.ORCID 0000-0001-5694-4201
Sijia WangMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, 200438, China.ORCID 0000-0001-6961-7867
Kaustubh AdhikariSchool of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, MK7 6AA, United Kingdom. kaustubh.adhikari@open.ac.uk.ORCID 0000-0001-5825-4191
Andrés Ruiz-LinaresMinistry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, 200438, China. andresruiz@fudan.edu.cn.ORCID 0000-0001-8372-1011
Universidad Peruana Cayetano Heredia · PECentre National de la Recherche Scientifique · FRFudan University · CNLaboratory of Molecular Genetics · PLThe Open University · GBUniversidad de Antioquia · COUniversidade Federal do Rio Grande do Sul · BRNational Institute of Genomic Medicine · MXUniversity of Tarapacá · CLCentro Científico Tecnológico Patagónico · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARFederal Police of Brazil · BRInstitut Pasteur · FRNatural History Museum · GBShanghai Institute of Nutrition and Health · CNUniversidade de São Paulo · BRUniversidad Nacional Autónoma de México · MX
Funding
Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7MThe Genetic Architecture of Human Facial MorphologyR01DE027023 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLAES, PETER, SHAFFER, JOHN R · 2017 to 2024
$5.2M3D Analysis of Normal Facial Variation: Data Repository and Genetics (Research)U01DE020078 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2009 to 2013
$2.0MNIDCR NIH HHS R01 DE016148NIDCR NIH HHS R01 DE027023NIDCR NIH HHS U01 DE020078
Abstract
We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value <5 × 10
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NeanderthalsAnimalsCell DifferentiationGenome-Wide Association StudyHumansMiceNose
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