Evidence map›Paper›PMID 37156915›Full record

ArticleNature biotechnology2024

Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.

Xiaomeng Hu, Kathy White, Ari G Olroyd, Rowena DeJesus, Antonia A Dominguez, William E Dowdle, Annabelle M Friera, Chi Young, Frank Wells, Elaine Y Chu and 19 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
42.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 134 citations in OpenAlex.

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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 5 institutions in 1 country.

Xiaomeng HuSana Biotechnology, Inc., South San Francisco, CA, USA.
Kathy WhiteSana Biotechnology, Inc., South San Francisco, CA, USA.
Ari G OlroydSana Biotechnology, Inc., South San Francisco, CA, USA.
Rowena DeJesusSana Biotechnology, Inc., South San Francisco, CA, USA.
Antonia A DominguezSana Biotechnology, Inc., South San Francisco, CA, USA.
William E DowdleSana Biotechnology, Inc., South San Francisco, CA, USA.
Annabelle M FrieraSana Biotechnology, Inc., South San Francisco, CA, USA.
Chi YoungSana Biotechnology, Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2424-0060
Frank WellsSana Biotechnology, Inc., South San Francisco, CA, USA.
Elaine Y ChuSana Biotechnology, Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9493-5859
Cade Ellis ItoSana Biotechnology, Inc., South San Francisco, CA, USA.
Harini KrishnapuraSana Biotechnology, Inc., South San Francisco, CA, USA.
Surbhi JainSana Biotechnology, Inc., South San Francisco, CA, USA.
Ramya AnkalaSana Biotechnology, Inc., South San Francisco, CA, USA.
Trevor J McGillSana Biotechnology, Inc., South San Francisco, CA, USA.
August LinSana Biotechnology, Inc., South San Francisco, CA, USA.
Kyla EgenbergerSana Biotechnology, Inc., South San Francisco, CA, USA.
Allison GagnonSana Biotechnology, Inc., South San Francisco, CA, USA.
J Michael RukstalisSana Biotechnology, Inc., South San Francisco, CA, USA.
Nathaniel J HogrebeDivision of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.
Corie GattisSana Biotechnology, Inc., South San Francisco, CA, USA.
Ron BascoSana Biotechnology, Inc., South San Francisco, CA, USA.
Jeffrey R MillmanSana Biotechnology, Inc., South San Francisco, CA, USA.
Paul KievitDivision of Cardiometabolic Health, Oregon National Primate Research Center, Beaverton, OR, USA.
Mark M DavisHoward Hughes Medical Institute, Institute for Immunity, Transplantation and Infection, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Lewis L LanierDepartment of Microbiology and Immunology and the Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1308-3952
Andrew J ConnollyDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Tobias Deuse *Transplant and Stem Cell Immunobiology (TSI) Lab, Department of Surgery, Division of Cardiothoracic Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9695-4006
Sonja Schrepfer *Sana Biotechnology, Inc., South San Francisco, CA, USA. sonja.schrepfer@sana.com.ORCID http://orcid.org/0000-0002-7696-6229
Sana Biotechnology (United States) · USUniversity of California, San Francisco · USHoward Hughes Medical Institute · USOregon National Primate Research Center · USWashington University in St. Louis · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a recipient's immune system would abolish the requirement for immunosuppressive drugs or encapsulation and support large-scale manufacturing of off-the-shelf cell products. Previously, we generated mouse and human hypoimmune pluripotent (HIP) stem cells by depleting HLA class I and II molecules and overexpressing CD47 (B2M

Indexed as

Hematopoietic Stem Cell TransplantationInduced Pluripotent Stem CellsIslets of Langerhans TransplantationAnimalsCD47 AntigenGraft RejectionMacaca mulattaMiceCD47 Antigen

Identifiers

PMID37156915
PMCPMC10940156
OpenAlexW4375858821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.