Evidence map›Paper›PMID 37156880›Full record

ArticleActa neuropathologica2023

A novel subtype of sporadic Creutzfeldt-Jakob disease with PRNP codon 129MM genotype and PrP plaques.

Rabeah Bayazid, Christina Orru', Rabail Aslam, Yvonne Cohen, Amelia Silva-Rohwer, Seong-Ki Lee, Rossana Occhipinti, Qingzhong Kong, Shashirekha Shetty, Mark L Cohen and 4 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Tracking Prions by RT-QuIC: An Update.Sub-cellular biochemistry · 2025
    Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Rabeah BayazidDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Christina Orru'Laboratory of Persistent Viral Diseases, NIH, Hamilton, MT, USA.
Rabail AslamDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Yvonne CohenDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Amelia Silva-RohwerDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Seong-Ki LeeDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Rossana OcchipintiDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Qingzhong KongDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Shashirekha ShettyDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Mark L CohenDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Byron CaugheyLaboratory of Persistent Viral Diseases, NIH, Hamilton, MT, USA.
Lawrence B SchonbergerDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Brian S ApplebyDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Ignazio CaliDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. ixc20@case.edu.ORCID 0000-0001-5770-3848
Case Western Reserve University · USCenters for Disease Control and Prevention · USUniversity Hospitals Cleveland Medical Center · US

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Jason C Bartz · 2008 to 2026
$36.1M
Detection of PrionsZIAAI001086 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CAUGHEY, BYRON · 2009 to 2025
$18.1M
Conformational properties of misfolded protein aggregates in cases involving the co-occurrence of prion disease and Alzehimer's disease or prion disease and CTER00AG068359 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI CALI, IGNAZIO · 2022 to 2023
$498k
Conformational properties of misfolded protein aggregates in cases involving the co-occurrence of prion disease and Alzehimer's disease or prion disease and CTEK99AG068359 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI CALI, IGNAZIO · 2020 to 2021
$242k
NIAID NIH HHS P01 AI077774NIA NIH HHS K99 AG068359NIA NIH HHS R00 AG068359
6 · The paper itself

Abstract

The presence of amyloid kuru plaques is a pathological hallmark of sporadic Creutzfeldt-Jakob disease (sCJD) of the MV2K subtype. Recently, PrP plaques (p) have been described in the white matter of a small group of CJD (p-CJD) cases with the 129MM genotype and carrying resPrP

Indexed as

Creutzfeldt-Jakob SyndromePrionsAnimalsBrainCodonGenotypeHumansMiceMice, TransgenicPlaque, AmyloidPrion ProteinsCodonPrion ProteinsPrionsPRNP protein, humanGray matterPhenotypePrion diseasePrion strainPrP plaquesWhite matter

Identifiers

PMID37156880
PMCPMC10166463
OpenAlexW4375858386

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.