ArticleThe ISME journal2023
Predation of oomycetes by myxobacteria via a specialized CAZyme system arising from adaptive evolution.
Article in The ISME journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- Enhanced Endophytic Colonization of Flavobacterium Promotes Plant Resistance to Fusarium Wilt.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Predatory Mechanisms of Myxobacteria and Their Potential in the Development of Biocontrol Agents.Journal of microbiology and biotechnology · 2026Review
- Identification of Novel Polysaccharide from Myxococcus xanthus and its Function in Developmental Sporulation.Current microbiology · 2026Article
- A predator-prey interaction between myxobacteria and fungi mediated by outer membrane vesicles.Journal of advanced research · 2026Article
- Role of DKxanthenes inJournal of microbiology and biotechnology · 2026Article
- Predator avoidance promotes inter-bacterial symbiosis with myxobacteria in polymicrobial communities.bioRxiv : the preprint server for biology · 2026Article
- Optimized fermentation of Myxococcus fulvus WCH05 enhances biocontrol of pear fire blight in the field.BMC microbiology · 2026Article
- Predator avoidance promotes interbacterial symbiosis with myxobacteria in polymicrobial communities.The ISME journal · 2026Article
- Biocontrol of watermelon Fusarium wilt caused byFrontiers in microbiology · 2026Article
- Myxobacteria: Versatile cell factories of novel commercial enzymes for bio-manufacturing.Biotechnology advances · 2025Review
- South African Myxococcota: an untapped resource for microbial ecolo gy and biotechnology.Applied microbiology and biotechnology · 2025Review
- Genomic insights into novel predatory myxobacteria isolated from human feces.Microbiology spectrum · 2025Article
- Nature's Arsenal: Uncovering Antibacterial Agents Against Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2025Review
- Comparative genomic insight into the myxobacterial carbohydrate-degrading potential.Frontiers in microbiology · 2025Article
- Article
- A hunting ground for predatory bacteria at the Zhenbei seamount in the South China Sea.ISME communications · 2025Article
- Biogeographical distribution and community assembly of Myxococcota in mangrove sediments.Environmental microbiome · 2024Article
- Unveiling Agricultural Biotechnological Prospects: The Draft Genome Sequence of Stenotrophomonas geniculata LGMB417.Current microbiology · 2024Article
- Corrigendum: Active substances of myxobacteria against plant diseases and their action mechanisms.Frontiers in microbiology · 2024Article
- Secretory CAZymes profile and GH19 enzymes analysis ofFrontiers in microbiology · 2024Article
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As social micropredators, myxobacteria are studied for their abilities to prey on bacteria and fungi. However, their predation of oomycetes has received little attention. Here, we show that Archangium sp. AC19 secretes a carbohydrate-active enzyme (CAZyme) cocktail during predation on oomycetes Phytophthora. These enzymes include three specialized β-1,3-glucanases (AcGlu13.1, -13.2 and -13.3) that act as a cooperative consortium to target β-1,3-glucans of Phytophthora. However, the CAZymes showed no hydrolytic effects on fungal cells, even though fungi contain β-1,3-glucans. Heterologous expression of AcGlu13.1, -13.2 or -13.3 enzymes in Myxococcus xanthus DK1622, a model myxobacterium that antagonizes but does not predate on P. sojae, conferred a cooperative and mycophagous ability that stably maintains myxobacteria populations as a mixture of engineered strains. Comparative genomic analyses suggest that these CAZymes arose from adaptive evolution among Cystobacteriaceae myxobacteria for a specific prey killing behavior, whereby the presence of Phytophthora promotes growth of myxobacterial taxa by nutrient release and consumption. Our findings demonstrate that this lethal combination of CAZymes transforms a non-predatory myxobacterium into a predator with the ability to feed on Phytophthora, and provides new insights for understanding predator-prey interactions. In summary, our work extends the repertoire of myxobacteria predatory strategies and their evolution, and suggests that these CAZymes can be engineered as a functional consortium into strains for biocontrol of Phytophothora diseases and hence crop protection.
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