ArticleNature communications2023
Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- <p>Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)</p>.International journal of molecular medicine · 2026Review
- Differential analysis of image-based chromatin tracing data with Dory.bioRxiv : the preprint server for biology · 2026Article
- CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer.Bioactive materials · 2025Article
- Unraveling the Role of Leukotriene A4 Hydrolase in Hepatocellular Carcinoma: Implications for Targeted Therapy and Tumor Progression.Digestive diseases and sciences · 2025Article
- Whole-gene CRISPR/cas9 library screen revealed targeting STAT6 increased the sensitivity of liver cancer to celecoxib via inhibiting arachidonic acid shunting.Cell communication and signaling : CCS · 2025Article
- A pH-sensitive peptide amphiphilic-based drug delivery system inhibits hepatocellular carcinoma growth by suppressing hepatic stellate cell activation.Materials today. Bio · 2025Article
- MTFR2-Mediated Fission Drives Fatty Acid and Mitochondrial Co-Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN-L/PINK1/parkin mediated mitophagy in mouse.FASEB bioAdvances · 2025Article
- Defined Diets Link Iron and α-Linolenic Acid to Cyp1b1 Regulation of Neonatal Liver Development Through Srebp Forms and LncRNA H19.International journal of molecular sciences · 2025Article
- Autonomic nervous system development-related signature as a novel predictive biomarker for immunotherapy in pan-cancers.Frontiers in immunology · 2025Article
- Correlation between gut microbiota and their metabolites and the efficacy of chemotherapy combined with immunotherapy for extensive-stage small cell lung cancer.Frontiers in oncology · 2025Article
- Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review).International journal of oncology · 2024Review
- Revolutionizing digestive system tumor organoids research: Exploring the potential of tumor organoids.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 3 countries.
Sonal SinhaSouthern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Satoka AizawaSouthern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Yasuhiro NakanoLaboratory of Cell Growth and Differentiation, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, 113-0022, Japan.ORCID 0000-0002-8094-3185
Alexander RialdiIcahn School of Medicine at Mount Sinai Hess Center for Science and Medicine, New York, NY, 10029, USA.
Hye Yeon ChoiSouthern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Rajan ShresthaSouthern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Stephanie Q PanSouthern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Yibu ChenUSC Libraries Bioinformatics Services of the University of Southern California, Los Angeles, CA, 90089, USA.
Meng LiUSC Libraries Bioinformatics Services of the University of Southern California, Los Angeles, CA, 90089, USA.
Audrey Kapelanski-LamoureuxResearch Institute of the McGill University Health Centre, Montreal, QC, H3A 0G4, Canada.ORCID 0000-0002-4650-6141
Gregory YochumDepartment of Surgery, Pennsylvania State University, Hershey, PA, 17033, USA.
Linda SherDepartment of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Satdarshan Paul MongaDepartment of Pathology, University of Pittsburg School of Medicine, Pittsburg, PA, 15213, USA.ORCID 0000-0002-8437-3378
Anthoula LazarisResearch Institute of the McGill University Health Centre, Montreal, QC, H3A 0G4, Canada.ORCID 0000-0002-2173-7891
Keigo MachidaSouthern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.ORCID 0000-0002-9721-8553
Michael KarinDepartment of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.
Ernesto GuccioneIcahn School of Medicine at Mount Sinai Hess Center for Science and Medicine, New York, NY, 10029, USA.
Hidekazu TsukamotoSouthern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA. htsukamo@med.usc.edu.ORCID 0000-0002-6833-2998
University of Southern California · USIcahn School of Medicine at Mount Sinai · USMcGill University Health Centre · CAPennsylvania State University · USPittsburg State University · USThe University of Tokyo · JPUniversity of California San Diego · US
Funding
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CARYN LERMAN · 1985 to 2026
$181.4MThe Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8MTHE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4MUSC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI OOKHTENS, MURAD · 1995 to 2020
$21.8MNuclear Receptors in Liver Health and DiseaseP20GM103549 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2012 to 2015
$8.1MNON-PARENCHYMAL LIVER CELL CORER24AA012885 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TSUKAMOTO, HIDEKAZU · 2001 to 2025
$8.1MPilot Grants ProgramP30GM118247 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2016 to 2020
$5.5MImmunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitorsU01AA027681 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EL-KHOUEIRY, ANTHONY BOUTROS, KARIN, MICHAEL · 2018 to 2022
$3.6MAN INTEGRATED PLATFORM FOR NOVEL PERSONALIZED LIVER CANCER THERAPEUTICSR01CA256480 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAR, ARVIN, GUCCIONE, ERNESTO · 2021 to 2025
$3.3MHepatocyte-derived extracellular vesicles in alcoholic liver diseaseR01AA028134 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL, TSUKAMOTO, HIDEKAZU · 2020 to 2024
$2.9MHighly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitorsR01CA234128 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL · 2019 to 2023
$2.7MTherapeutic targeting of RNA splicing catalysis through inhibition of Protein Arginine MethylationR01CA249204 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GUCCIONE, ERNESTO · 2020 to 2024
$2.5MBLRD VA I01 BX001991BLRD VA IK6 BX004205NCI NIH HHS F32 CA247414NCI NIH HHS K99 CA273538NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA196521NCI NIH HHS R01 CA234128NCI NIH HHS R01 CA248984NCI NIH HHS R01 CA249204NCI NIH HHS R01 CA256480NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA025204NIAAA NIH HHS R01 AA028134NIAAA NIH HHS R24 AA012885NIAAA NIH HHS U01 AA027681NIDDK NIH HHS P30 DK048522NIGMS NIH HHS P20 GM103549NIGMS NIH HHS P30 GM118247
Abstract
Hepatocellular carcinoma (HCC) is the 3
Indexed as
Carcinoma, HepatocellularLiver NeoplasmsAnimalsbeta CateninCarcinogenesisFatty Acid DesaturasesHepatic Stellate CellsMaleMiceReceptors, Leukotriene B4Stearoyl-CoA DesaturaseTumor Microenvironmentbeta CateninFatty Acid DesaturasesReceptors, Leukotriene B4Scd2 protein, mouseStearoyl-CoA Desaturase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.