ArticleNeurology2023
Associations of Enlarged Perivascular Spaces With Brain Lesions, Brain Age, and Clinical Outcomes in Chronic Traumatic Brain Injury.
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Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Transdiagnostic MRI-derived Features of Psychopathology Following Traumatic Brain Injury: A Systematic Review.Neuropsychology review · 2026Review
- Article
- Prognostic value of magnetic resonance imaging-visible perivascular spaces in patients with idiopathic normal pressure hydrocephalus.Quantitative imaging in medicine and surgery · 2026Article
- Do enlarged white matter perivascular spaces reflect brain clearance dysfunction? Insights from intrathecal contrast-enhanced MRI.Neuroradiology · 2026Article
- The glymphatic system in neurodegenerative diseases and brain tumors: mechanistic insights, biomarker advances, and therapeutic opportunities.Acta neuropathologica communications · 2025Review
- Perceiving traumatic brain injury from glymphatic system.Molecular psychiatry · 2025Review
- Increased burden of enlarged perivascular spaces in patients with patent foramen ovale.Neuroradiology · 2025Article
- Near-Infrared Imaging of Glymphatic Clearance in a Pre-Clinical Model of Repetitive Closed Head Traumatic Brain Injury.Neurotrauma reports · 2025Article
- Plasma biomarkers in chronic single moderate-severe traumatic brain injury.Brain : a journal of neurology · 2024Article
- Perivascular Space Burden and Cerebrospinal Fluid Biomarkers in US Veterans With Blast-Related Mild Traumatic Brain Injury.Journal of neurotrauma · 2024Article
- Longitudinal Assessment of Glymphatic Changes Following Mild Traumatic Brain Injury: Insights from PVS burden and DTI-ALPS Imaging.medRxiv : the preprint server for health sciences · 2024Article
- The glymphatic system for neurosurgeons: a scoping review.Neurosurgical review · 2024Article
- A bibliometric analysis of the relationship between traumatic brain injury and Alzheimer's disease (1993-2023).Frontiers in aging neuroscience · 2024Article
- Change in Enlarged Perivascular Spaces over Time and Associations with Outcomes After Traumatic Brain Injury.Neurotrauma reports · 2024Article
- Impaired glymphatic system in genetic frontotemporal dementia: a GENFI study.Brain communications · 2024Article
- Longitudinal assessment of glymphatic changes following mild traumatic brain injury: Insights from perivascular space burden and DTI-ALPS imaging.Frontiers in neurology · 2024Article
- Lifetime history of head injury is associated with reduced perivascular space number in acute mild traumatic brain injury.Brain communications · 2024Article
- Unraveling the Predictors of Enlarged Perivascular Spaces: A Comprehensive Logistic Regression Approach in Cerebral Small Vessel Disease.International journal of general medicine · 2024Article
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Authors and funding
10 authors at 6 institutions in 3 countries.
Amelia J HicksFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.ORCID 0000-0002-1152-0576
Benjamin SinclairFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.
Sandy R ShultzFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.
William PhamFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.
Lisa C SilbertFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.
Daniel L SchwartzFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.
Christopher C RoweFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.ORCID 0000-0003-3910-2453
Jennie L PonsfordFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.ORCID 0000-0003-0430-125X
Meng LawFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia.
Gershon SpitzFrom the Monash-Epworth Rehabilitation Research Centre (A.J.H., J.L.P., G.S.), Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Department of Neuroscience (A.J.H., B.S., S.R.S., W.P., M.L., G.S.), Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton; Department of Neurology (B.S.), Alfred Health, Melbourne, Australia; Health and Human Services (S.S.), Vancouver Island University, Nanaimo; Division of Medical Sciences (S.S.), University of Victoria, British Columbia, Canada; NIA-Layton Oregon Aging & Alzheimer's Disease Research Center (L.C.S., D.L.S.), Oregon Health & Science University; Department of Neurology (L.C.S.), Portland Veterans Affairs Health Care System; Advanced Imaging Research Center (D.L.S.), Oregon Health & Science University, Portland; Department of Molecular Imaging and Therapy (C.C.R.), Austin Health, Heidelberg; Florey Department of Neuroscience and Mental Health (C.C.R.), University of Melbourne, Parkville; and Department of Radiology (M.L.), Alfred Health, Melbourne, Australia. gershon.spitz@monash.edu.ORCID 0000-0002-7810-1480
Monash University · AUAlfred Health · AUAustin Health · AUOregon Health & Science University · USUniversity of Victoria · CAVA Portland Health Care System · US
Funding
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6MNIA NIH HHS P30 AG066518
Abstract
BACKGROUND AND
objectivesEnlarged perivascular spaces (ePVS) have been identified as a key signature of glymphatic system dysfunction in neurologic conditions. The incidence and clinical implications of ePVS after traumatic brain injury (TBI) are not yet understood. We investigated whether individuals with chronic moderate-to-severe TBI had an increased burden of ePVS and whether ePVS burden is modulated by the presence of focal lesions, older brain age, and poorer sleep quality. We examined whether an increased burden of ePVS was associated with poorer cognitive and emotional outcomes.
methodsUsing a cross-sectional design, participants with a single moderate-to-severe chronic TBI (sustained ≥10 years ago) were recruited from an inpatient rehabilitation program. Control participants were recruited from the community. Participants underwent 3T brain MRI, neuropsychological assessment, and clinical evaluations. ePVS burden in white matter was quantified using automated segmentation. The relationship between the number of ePVS, group membership, focal lesions, brain age, current sleep quality, and outcome was modeled using negative binomial and linear regressions.
resultsThis study included 100 participants with TBI (70% male; mean age = 56.8 years) and 75 control participants (54.3% male; mean age = 59.8 years). The TBI group had a significantly greater burden of ePVS (prevalence ratio rate [PRR] = 1.29, DISCUSSION: TBI is associated with a greater burden of ePVS, especially when there have been bilateral brain lesions. ePVS was associated with reduced verbal memory performance. ePVS may indicate ongoing impairments in glymphatic system function in the chronic postinjury period.
Indexed as
Brain Injuries, TraumaticGlymphatic SystemNervous System DiseasesBrainCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle Aged
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