Evidence map›Paper›PMID 37156611›Full record

ArticleeNeuro2023

A History of Low-Dose Ethanol Shifts the Role of Ventral Hippocampus during Reward Seeking in Male Mice.

Kathleen G Bryant, Mitchell A Nothem, Lauren A Buck, Binay Singh, Sana Amin, Christina M Curran-Alfaro, Jacqueline M Barker

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kathleen G BryantDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102.ORCID 0000-0002-5084-0863
Mitchell A NothemDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102.
Lauren A BuckDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102.
Binay SinghDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102.
Sana AminDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102.
Christina M Curran-AlfaroDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102.
Jacqueline M BarkerDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102 jmb893@drexel.edu.
Drexel University · US

Funding

Arbitration Between Goal-directed and Habitual Ethanol Seeking by the Nucleus Accumbens Shell.R00AA024499 · NIAAA · DREXEL UNIVERSITY · PI BARKER, JACQUELINE M · 2018 to 2020
$747k
Sex differences in regulation of reinstatement of ethanol seeking by nucleus accumbens glutamate signalingR21AA027629 · NIAAA · DREXEL UNIVERSITY · PI BARKER, JACQUELINE M · 2020 to 2021
$397k
Low dose ethanol effects on reward learning and motivationF31AA029621 · NIAAA · DREXEL UNIVERSITY · PI BRYANT, KATHLEEN GRACE · 2021 to 2022
$93k
NIAAA NIH HHS F31 AA029621NIAAA NIH HHS R00 AA024499NIAAA NIH HHS R21 AA027629
6 · The paper itself

Abstract

Although casual drinkers are a majority of the alcohol drinking population, understanding of the long-term effects of chronic exposure to lower levels of alcohol is limited. Chronic exposure to lower doses of ethanol may facilitate the development of alcohol use disorders, potentially because of ethanol effects on reward learning and motivation. Indeed, our previously published findings showed that chronic low-dose ethanol exposure enhanced motivation for sucrose in male, but not female, mice. As the ventral hippocampus (vHPC) is sensitive to disruption by higher doses of chronic ethanol and tracks reward-related information, we hypothesized that this region is impacted by low-dose ethanol and, further, that manipulating vHPC activity would alter reward motivation.

Indexed as

AlcoholismEthanolAnimalsConditioning, OperantHippocampusMaleMiceRewardSucroseEthanolSucroseelectrophysiologyethanolhippocampusmotivationoperantoptogenetics

Identifiers

PMID37156611
PMCPMC10198604
OpenAlexW4375954822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.