Evidence map›Paper›PMID 37156373›Full record

ArticleContemporary clinical trials2023

The effects of strEngth aNd BaLance exercise on Executive function in people living with Dementia (ENABLED): Study protocol for a pilot randomized controlled trial.

Deborah A Jehu, Yanbin Dong, Haidong Zhu, Ying Huang, Andre Soares, Charmi Patel, Zak Aden, Colleen Hergott, Brittany Ange, Jennifer L Waller and 6 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05488951 (The Effects of strEngth aNd BaLance Exercise on Executive Function in People Living With Dementia), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05488951 naunknown statusnot on this map

The Effects of strEngth aNd BaLance Exercise on Executive Function in People Living With Dementia (ENABLED): A Randomized Controlled Trial

TypeinterventionalSponsorAugusta UniversityRan2022 to 2023Enrolled42ConditionsDementiaArmsOtago Exercise Program
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Deborah A JehuInterdisciplinary Health Sciences Department, College of Allied Health Sciences, Augusta University, Augusta, GA, USA. Electronic address: djehu@augusta.edu.
Yanbin DongGeorgia Prevention Institute, Augusta University, Augusta, GA, USA. Electronic address: ydong@augusta.edu.
Haidong ZhuGeorgia Prevention Institute, Augusta University, Augusta, GA, USA. Electronic address: hzhu@augusta.edu.
Ying HuangGeorgia Prevention Institute, Augusta University, Augusta, GA, USA. Electronic address: yihuang@augusta.edu.
Andre SoaresInterdisciplinary Health Sciences Department, College of Allied Health Sciences, Augusta University, Augusta, GA, USA. Electronic address: ansoares@augusta.edu.
Charmi PatelInterdisciplinary Health Sciences Department, College of Allied Health Sciences, Augusta University, Augusta, GA, USA. Electronic address: cpatel5@augusta.edu.
Zak AdenInterdisciplinary Health Sciences Department, College of Allied Health Sciences, Augusta University, Augusta, GA, USA. Electronic address: zaden@augusta.edu.
Colleen HergottPhysical Therapy Department, College of Allied Health Sciences, Augusta University, USA. Electronic address: chergott@augusta.edu.
Brittany AngeDepartment of Population Health Sciences, Division of Biostatistics and Data Science, Augusta University, USA. Electronic address: bange@augusta.edu.
Jennifer L WallerDepartment of Population Health Sciences, Division of Biostatistics and Data Science, Augusta University, USA. Electronic address: jwaller@augusta.edu.
Lufei YoungSchool of Nursing, University of North Carolina, Charlotte, NC, USA. Electronic address: lyoung57@uncc.edu.
William HallClaiborne Assisted Living Facility, GA College of Nursing, Augusta University, Augusta, GA, USA. Electronic address: whall@theclaiborne.com.
Dawnchelle Robinson-JohnsonClaiborne Assisted Living Facility, GA College of Nursing, Augusta University, Augusta, GA, USA. Electronic address: drobinsonjohnson@theclaiborne.com.
Crystal AllenGeorgia War Veterans Nursing Home, Augusta, GA, USA. Electronic address: callen11@augusta.edu.
Richard SamsGeorgia War Veterans Nursing Home, Augusta, GA, USA. Electronic address: risams@augusta.edu.
Mark HamrickDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: mhamrick@augusta.edu.
Augusta University · USAugusta University Health · USPrevention Institute · USUniversity of North Carolina at Charlotte · US

Funding

THE LEPTIN-IGF1 AXIS IN MUSCULOSKELETAL AGINGP01AG036675 · NIA · AUGUSTA UNIVERSITY · PI CARLOS M. ISALES · 2011 to 2026
$31.5M
NIA NIH HHS P01 AG036675
6 · The paper itself

Abstract

backgroundExercise may improve executive function among people living with all-cause dementia (PWD), but more evidence is needed. The aim of this pilot randomized controlled trial (RCT) is to examine whether exercise plus usual care improves the primary outcome of executive function, and secondary physiological (inflammation, metabolic aging, epigenetics) and behavioral (cognition, psychological health, physical function, and falls) outcomes compared to usual care alone among PWD. METHODS AND STUDY

designThe strEngth aNd BaLance exercise on Executive function in people living with Dementia (ENABLED) protocol is a pilot parallel, 6-month assessor-blinded RCT (1:1) in residential care facilities, including n = 21 receiving exercise plus usual care and n = 21 usual care alone [NCT05488951]. We will collect primary (Color-Word Stroop Test) and secondary physiological (inflammation, metabolic aging, epigenetics) and behavioral (cognition, psychological health, physical function, and falls) outcomes at baseline and 6 months. We will obtain falls monthly from medical charts. We will collect physical activity, sedentary behavior, and sleep via wrist-worn accelerometers over 7 days at baseline and 6 months. The physical therapist-led adapted Otago Exercise Program will involve 1-h of strength, balance and walking 3×/week for 6 months in groups of 5-7. We will use generalized linear mixed models to examine differences over time in primary and secondary outcomes between groups and examine potential interactions with sex and race. DISCUSSION: This pilot RCT will examine the direct effects and potential underlying physiological mechanisms of exercise on executive function and other behavioral outcomes in PWD, which may have implications for clinical care management.

Indexed as

DementiaExecutive FunctionExercise TherapyFemaleHumansInflammationMalePilot ProjectsPostural BalanceRandomized Controlled Trials as TopicBalanceDementiaExecutive functionExerciseFallsInflammation

Identifiers

PMID37156373
PMCPMC10330466
OpenAlexW4372311764

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.