Evidence map›Paper›PMID 37156179›Full record

ArticleNeurobiology of aging2023

Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia.

Arunima Kapoor, Aimée Gaubert, Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, John Paul M Alitin, Amy Nguyen, Jean K Ho, Anna E Blanken and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Arunima KapoorDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Aimée GaubertInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Belinda YewDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
John Paul M AlitinInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Amy NguyenInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Anna E BlankenSan Francisco Veterans Affairs Health Care System & Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Isabel J SibleDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Anisa MarshallDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Fatemah ShenasaDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA.
Kathleen E RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Alessandra C MartiniDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.
Daniel A NationDepartment of Psychological Science, University of California, Irvine, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA. Electronic address: dnation@uci.edu.
University of California, Irvine · USUniversity of Southern California · USUniversity of Arizona · USUniversity of California, San Francisco · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066530NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228
6 · The paper itself

Abstract

Dilation of perivascular spaces (PVS) in the brain may indicate poor fluid drainage due to the accumulation of perivascular cell debris, waste, and proteins, including amyloid-beta (Aβ). No prior study has assessed whether plasma Aβ levels are related to PVS in older adults without dementia. Independently living older adults (N = 56, mean age = 68.2 years; Standard deviation (SD) = 6.5; 30.4% male) free of dementia or clinical stroke were recruited from the community and underwent brain MRI and venipuncture. PVS were qualitatively scored and dichotomized to low PVS burden (scores 0-1,) or high PVS burden (score>1). Plasma was assayed using a Quanterix Simoa Kit to quantify Aβ42 and Aβ40 levels. A significant difference was observed in plasma Aβ42/Aβ40 ratio between low and high PVS burden, controlling for age (F[1, 53] = 5.59, p = 0.022, η

Indexed as

Alzheimer DiseaseAgedAmyloid beta-PeptidesBiomarkersBrainFemaleHumansMalePeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)BiomarkersPeptide FragmentsAlzheimer’s diseaseAβ42/Aβ40 RatioPerivascular spacesSmall vessel diseaseVascular cognitive impairment

Identifiers

PMID37156179
PMCPMC10852216
OpenAlexW4365511452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.