Evidence map›Paper›PMID 37156006›Full record

ReviewACS chemical neuroscience2023

Gut Microbiome-Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders.

Janet M Sasso, Ramy M Ammar, Rumiana Tenchov, Steven Lemmel, Olaf Kelber, Malte Grieswelle, Qiongqiong Angela Zhou

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ACS chemical neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 3 pooled it
33.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 3 syntheses or guidelines pooled it, 177 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Review
  9. Article
  10. Observational
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Observational
  18. Article
  19. Review
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Janet M SassoCAS, a division of the American Chemical Society, 2540 Olentangy River Rd, Columbus, Ohio 43202, United States.ORCID 0000-0002-1156-5184
Ramy M AmmarBayer Consumer Health, R&D Digestive Health, Darmstadt 64295, Germany.
Rumiana TenchovCAS, a division of the American Chemical Society, 2540 Olentangy River Rd, Columbus, Ohio 43202, United States.ORCID 0000-0003-4698-6832
Steven LemmelCAS, a division of the American Chemical Society, 2540 Olentangy River Rd, Columbus, Ohio 43202, United States.
Olaf KelberBayer Consumer Health, R&D Digestive Health, Darmstadt 64295, Germany.
Malte GrieswelleBayer Consumer Health, R&D Digestive Health, Darmstadt 64295, Germany.
Qiongqiong Angela ZhouCAS, a division of the American Chemical Society, 2540 Olentangy River Rd, Columbus, Ohio 43202, United States.ORCID 0000-0001-6711-369X
American Chemical Society · USBayer (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that the gut and brain are in constant bidirectional communication, of which gut microbiota and its metabolic production are a major component, and form the so-called gut microbiome-brain axis. Disturbances of microbiota homeostasis caused by imbalance in their functional composition and metabolic activities, known as dysbiosis, cause dysregulation of these pathways and trigger changes in the blood-brain barrier permeability, thereby causing pathological malfunctions, including neurological and functional gastrointestinal disorders. In turn, the brain can affect the structure and function of gut microbiota through the autonomic nervous system by regulating gut motility, intestinal transit and secretion, and gut permeability. Here, we examine data from the CAS Content Collection, the largest collection of published scientific information, and analyze the publication landscape of recent research. We review the advances in knowledge related to the human gut microbiome, its complexity and functionality, its communication with the central nervous system, and the effect of the gut microbiome-brain axis on mental and gut health. We discuss correlations between gut microbiota composition and various diseases, specifically gastrointestinal and mental disorders. We also explore gut microbiota metabolites with regard to their impact on the brain and gut function and associated diseases. Finally, we assess clinical applications of gut-microbiota-related substances and metabolites with their development pipelines. We hope this review can serve as a useful resource in understanding the current knowledge on this emerging field in an effort to further solving of the remaining challenges and fulfilling its potential.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaBrainCentral Nervous SystemGastrointestinal TractHumansbacteriabrainDGBIdysbiosisgutintestinementalmetabolitemicrobiotamicroorganism

Identifiers

PMID37156006
PMCPMC10197139
OpenAlexW4375956217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.