Evidence map›Paper›PMID 37155902›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.

Fu-Lien Hsieh, Tao-Hsin Chang, Sandra B Gabelli, Jeremy Nathans

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Development of the blood-brain barrier.Development (Cambridge, England) · 2026
    Review
  2. Article
  3. Differential Localization of β-Catenin Protein in CTNNB1 Mutant Endometrial Cancers Results in Distinct Transcriptional Profiles.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fu-Lien HsiehDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Tao-Hsin ChangDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-7242-2585
Sandra B GabelliDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0003-1205-5204
Jeremy NathansDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-8106-5460
Johns Hopkins University · US

Funding

Life Science and Biomedical technology Research center at NSLS-II LSBRP41GM111244 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI MCSWEENEY, SEAN · 2014 to 2018
$16.4M
The control of retinal vascular development by Norrin and Frizzled4R01EY018637 · NEI · JOHNS HOPKINS UNIVERSITY · PI NATHANS, JEREMY · 2008 to 2021
$5.5M
Identification of novel spermine oxidase (SMOX) inhibitors as probes for an emerging chemoprevention targetR01CA204345 · NCI · JOHNS HOPKINS UNIVERSITY · PI CASERO, ROBERT A., WOSTER, PATRICK M · 2016 to 2020
$3.4M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA204345NEI NIH HHS R01 EY018637NIGMS NIH HHS P41 GM111244
6 · The paper itself

Abstract

Diverse extracellular proteins negatively regulate WNT signaling. One such regulator is adenomatosis polyposis coli down-regulated 1 (APCDD1), a conserved single-span transmembrane protein. In response to WNT signaling in a variety of tissues,

Indexed as

Adenomatous Polyposis ColiMembrane Proteinsbeta CateninHumansIntracellular Signaling Peptides and ProteinsLipidsWnt Signaling PathwayAPCDD1 protein, humanbeta CateninIntracellular Signaling Peptides and ProteinsLipidsMembrane Proteinsextracellular domainlipid-binding proteinnegative feedback regulationWnt signalingX-ray structure

Identifiers

PMID37155902
PMCPMC10193966
OpenAlexW4375954771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.