Evidence map›Paper›PMID 37155898›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration.

Yanan Lyu, Alexander V Tschulakow, Kun Wang, Douglas E Brash, Ulrich Schraermeyer

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Chemiexcitation in Ex Vivo Porcine Skin Model.Pigment cell & melanoma research · 2025
    Article
  2. Article
  3. Screening for Biomarkers Related to Pigmentation and Formation in Vitiligo.Combinatorial chemistry & high throughput screening · 2025
    Article
  4. Review
  5. Quantum biology in ophthalmology.Eye (London, England) · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Reply to Pfeffer: Macular degeneration clues from comparative anatomy.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yanan LyuDivision of Experimental Vitreoretinal Surgery, Centre for Ophthalmology, University of Tuebingen, Tuebingen 72076, Germany.ORCID 0000-0002-6928-5994
Alexander V TschulakowDivision of Experimental Vitreoretinal Surgery, Centre for Ophthalmology, University of Tuebingen, Tuebingen 72076, Germany.ORCID 0000-0001-5112-8838
Kun WangDivision of Experimental Vitreoretinal Surgery, Centre for Ophthalmology, University of Tuebingen, Tuebingen 72076, Germany.ORCID 0000-0002-2216-8651
Douglas E BrashDepartment of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520-8040.ORCID 0000-0001-7437-9373
Ulrich SchraermeyerDivision of Experimental Vitreoretinal Surgery, Centre for Ophthalmology, University of Tuebingen, Tuebingen 72076, Germany.ORCID 0000-0002-7969-8426
Yale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Chemiexcitation: A New Mode of Skin DiseaseR01AR070851 · NIAMS · YALE UNIVERSITY · PI BRASH, DOUGLAS E · 2017 to 2020
$1.7M
NCATS NIH HHS UL1 TR001863NIAMS NIH HHS R01 AR070851
6 · The paper itself

Abstract

Age-related macular degeneration, Stargardt disease, and their

Indexed as

Macular DegenerationMelaninsAnimalsATP-Binding Cassette TransportersLipofuscinMiceRetinaRetinal Pigment EpitheliumAbca4 protein, mouseATP-Binding Cassette TransportersLipofuscinMelaninsage-related macular degenerationlipofuscin degradation, mouse modellipofuscin degradationradicalsretinal pigment epitheliumStargardt disease

Identifiers

PMID37155898
PMCPMC10194005
OpenAlexW4375955176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.