Evidence map›Paper›PMID 37155891›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

A dual-action antibiotic that kills

Jeshina Janardhanan, Choon Kim, Yuanyuan Qian, Jingdong Yang, Jayda E Meisel, Derong Ding, Enrico Speri, Valerie A Schroeder, William R Wolter, Allen G Oliver and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. A Potent and Narrow-Spectrum Antibacterial againstJournal of medicinal chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jeshina JanardhananDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Choon KimDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0003-0306-8935
Yuanyuan QianDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0003-4093-2067
Jingdong YangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Jayda E MeiselDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Derong DingDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Enrico SperiDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Valerie A SchroederDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
William R WolterFreimann Life Sciences Center, University of Notre Dame, Notre Dame, IN 46556.
Allen G OliverDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.
Shahriar MobasheryDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0002-7695-7883
Mayland ChangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0002-4333-3775
University of Notre Dame · US

Funding

Novel oxadiazols for the treatment of drug-resistant gram-positive bacteriaR01AI090818 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2010 to 2014
$5.0M
Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
The quinazolinone class of antibacterial agentsR01AI116548 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F · 2015 to 2019
$3.0M
Chemistry-Biochemistry-Biology Interface (CBBI) Program at Notre DameT32GM145773 · NIGMS · UNIVERSITY OF NOTRE DAME · PI Christian Corey Melander · 2022 to 2026
$1.5M
NIAID NIH HHS R01 AI090818NIAID NIH HHS R01 AI116548NIGMS NIH HHS T32 GM075762NIGMS NIH HHS T32 GM145773
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ClostridioidesClostridioides difficileAnimalsBacterial ProteinsMicePeptidoglycanSpores, BacterialBacterial ProteinsPeptidoglycanClostridioides difficileoxadiazolespore germination

Identifiers

PMID37155891
PMCPMC10193928
OpenAlexW4375954869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.