Evidence map›Paper›PMID 37155081›Full record

ArticleArchives of virology2023

Consensus insertion/deletions and amino acid variations of all coding and noncoding regions of the SARS-CoV-2 Omicron clades, including the XBB and BQ.1 lineages.

Hamong Suharsono, Bayu K Mahardika, Putu H Sudipa, Tri K Sari, Ida B K Suardana, Gusti N Mahardika

Abstract read
In one paragraph

Article in Archives of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hamong SuharsonoBiochemistry Laboratory, The Faculty of Veterinary Medicine, Udayana University, Denpasar, Bali, Indonesia.
Bayu K MahardikaThe Animal Biomedical and Molecular Biology Laboratory, Udayana University, Jl. Sesetan-Markisa 6A, Denpasar, 80223, Bali, Indonesia.
Putu H SudipaVeterinary Bacteriology and Mycology Laboratory, The Faculty of Veterinary Medicine, Udayana University, Denpasar, Bali, Indonesia.
Tri K SariVirology Laboratory, The Faculty of Veterinary Medicine, Udayana University, Denpasar, Bali, Indonesia.
Ida B K SuardanaVirology Laboratory, The Faculty of Veterinary Medicine, Udayana University, Denpasar, Bali, Indonesia.
Gusti N MahardikaThe Animal Biomedical and Molecular Biology Laboratory, Udayana University, Jl. Sesetan-Markisa 6A, Denpasar, 80223, Bali, Indonesia. gnmahardika@unud.ac.id.ORCID http://orcid.org/0000-0001-5525-0793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The currently dominant Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has swiftly diverged into clades. To predict the probable impact of these clades, the consensus insertions/deletions (indels) and amino acid substitutions of the whole genome of clades were compared with the original SARS-CoV-2 strain. The evolutionary history of representatives of clades and lineages was inferred using the maximum-likelihood method and tested using the bootstrap method. The indels and polymorphic amino acids were found to be either clade-specific or shared among clades. The 21K clade has unique indels and substitutions, which probably represent reverted indels/substitutions. Three variations that appear to be associated with SARS-CoV-2 attenuation in the Omicron clades included a deletion in the nucleocapsid gene, a deletion in the 3'untranslated region, and a truncation in open reading frame 8. Phylogenetic analysis showed that the Omicron clades and lineages form three separate clusters.

Indexed as

Amino AcidsCOVID-19ConsensusHumansPhylogenySARS-CoV-2Amino Acids

Identifiers

PMID37155081
PMCPMC10165275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.