ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2023
Heel quantitative ultrasound (QUS) predicts incident fractures independently of trabecular bone score (TBS), bone mineral density (BMD), and FRAX: the OsteoLaus Study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Comparative analysis of bone density measurement techniques: a systematic review of quantitative ultrasound and dual-energy X-ray absorptiometry.Frontiers in endocrinology · 2026Pooled it
- Calcaneal quantitative ultrasound parameters strongly correlate with DXA measurements in patients with acromegaly.Pituitary · 2026Observational
- Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Development and validation of an interpretable machine learning model for osteoporosis prediction using routine blood tests: a retrospective cohort study.BMC medical informatics and decision making · 2025Article
- Construction and validation of a multi-dimensional health indicator-driven osteoporosis risk prediction model: a large-sample cross-sectional study based on two centers.BMC musculoskeletal disorders · 2025Article
- Barriers and solutions for global access to osteoporosis management: a Position Paper from the International Osteoporosis Foundation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Review
- The association between glycemic indicators and bone mineral density and osteoporosis: a cross-sectional study.Scientific reports · 2025Article
- Testosterone Delays Bone Microstructural Destruction via Osteoblast-Androgen Receptor-Mediated Upregulation of Tenascin-C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank.Aging clinical and experimental research · 2025Article
- Assessment of Bone Health in Adult Patients with Inflammatory Bowel Disease: A Single-Center Cohort Study.Journal of clinical medicine · 2025Article
- Association Between Waist-to-Height Ratio Estimated Fat Mass Categories and Incident Fractures.Journal of cachexia, sarcopenia and muscle · 2025Article
- Causal association between female reproductive factors and periodontitis: evidence from Mendelian randomization study.Clinical oral investigations · 2025Article
- Global variation of low bone mineral density in special olympics adult athletes with intellectual and developmental disability-A cross-sectional study.PLOS global public health · 2025Article
- Muscle Performance as a Predictor of Bone Health: Among Community-Dwelling Postmenopausal Japanese Women from Setagaya-Aoba Study.Calcified tissue international · 2024Article
- Somatic Structure and Ultrasound Parameters of the Calcaneus Bone in Combat Sports Athletes in Relation to Vitamin DJournal of clinical medicine · 2024Article
- Enhancing Osteoblast Differentiation from Adipose-Derived Stem Cells Using Hydrogels and Photobiomodulation: Overcoming In Vitro Limitations for Osteoporosis Treatment.Current issues in molecular biology · 2024Review
- Systemic Capillary Responses to Acute Exercise in Hypertensive Seniors: Insights from a Single-Center Pilot Study.Journal of clinical medicine · 2024Article
- In Vivo Assessment of Bone Quality Without X-rays.Current osteoporosis reports · 2024Review
- Association of bone health by calcaneal quantitative ultrasound with quadriceps strength and function one year after unilateral total knee arthroplasty.Journal of orthopaedics · 2024Article
- Antipsychotic medication use in association with quantitative heel ultrasound (QUS).Bone reports · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to better define the role of heel-QUS in fracture prediction. Our results showed that heel-QUS predicts fracture independently of FRAX, BMD, and TBS. This corroborates its use as a case finding/pre-screening tool in osteoporosis management.
introductionQuantitative ultrasound (QUS) characterizes bone tissue based on the speed of sound (SOS) and broadband ultrasound attenuation (BUA). Heel-QUS predicts osteoporotic fractures independently of clinical risk factors (CRFs) and bone mineral density (BMD). We aimed to investigate whether (1) heel-QUS parameters predict major osteoporotic fractures (MOF) independently of the trabecular bone score (TBS) and (2) the change of heel-QUS parameters over 2.5 years is associated with fracture risk.
methodsOne thousand three hundred forty-five postmenopausal women from the OsteoLaus cohort were followed up for 7 years. Heel-QUS (SOS, BUA, and stiffness index (SI)), DXA (BMD and TBS), and MOF were assessed every 2.5 years. Pearson's correlation and multivariable regression analyses were used to determine associations between QUS and DXA parameters and fracture incidence.
resultsDuring a mean follow-up of 6.7 years, 200 MOF were recorded. Fractured women were older, more treated with anti-osteoporosis medication; had lower QUS, BMD, and TBS; higher FRAX-CRF risk; and more prevalent fractures. TBS was significantly correlated with SOS (0.409) and SI (0.472). A decrease of one SD in SI, BUA or SOS increased the MOF risk by (OR(95%CI)) 1.43 (1.18-1.75), 1.19 (0.99-1.43), and 1.52 (1.26-1.84), respectively, after adjustment for FRAX-CRF, treatment, BMD, and TBS. We found no association between the change of QUS parameters in 2.5 years and incident MOF.
conclusionHeel-QUS predicts fracture independently of FRAX, BMD, and TBS. Thus, QUS represents an important case finding/pre-screening tool in osteoporosis management. The change in QUS over time was not associated with future fractures, making it inappropriate for patient monitoring.
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