ArticleSkeletal radiology2023
Imaging of early-stage osteoarthritis: the needs and challenges for diagnosis and classification.
Article in Skeletal radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Lower patella-patellar tendon angle is associated with increased odds of patellofemoral osteoarthritis progression in ACL revision patients: A case control study.Journal of experimental orthopaedics · 2026Article
- Isolation of synovial fluid exosomes using phospholipid molecular imprinting technology and discovery of early diagnostic markers for osteoarthritis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Repeatability of SimultaneousNMR in biomedicine · 2026Article
- Longitudinal correlation between X-ray and MRI findings in medial compartment knee osteoarthritis: Insights into early cartilage loss and structural changes.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Exploratory analysis of the 2-year changes in knee cartilage thickness and transverse relaxation time (T2) in ACL-injured versus healthy participants.Osteoarthritis and cartilage open · 2026Article
- Frequency and mutual associations of knee osteoarthritis features on ultrasound imaging in recent-onset symptomatic knee osteoarthritis patients: A cross-sectional analysis in a convenience sample of Dutch patients.Osteoarthritis and cartilage open · 2026Article
- Higher Prevalence of Sarcopenia in Knee Osteoarthritis and Its Association with Femoral Intercondylar Cartilage Thickness and Functional Outcomes.Life (Basel, Switzerland) · 2025Article
- A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention.International journal of molecular sciences · 2025Review
- Early diagnosis and targeted intervention based on the pathogenesis of rapidly progressive osteoarthritis of the hip.World journal of orthopedics · 2025Review
- TurkerNeXtV2: An Innovative CNN Model for Knee Osteoarthritis Pressure Image Classification.Diagnostics (Basel, Switzerland) · 2025Article
- Emerging Diagnostic Approaches for Musculoskeletal Disorders: Advances in Imaging, Biomarkers, and Clinical Assessment.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- The Presentation, Clinical Diagnosis, Risk Factors, and Management of Rapidly Progressive Hip Osteoarthritis: A Narrative Literature Review.Journal of clinical medicine · 2024Review
- Article
- Advanced nanoparticles in osteoarthritis treatment.Biomaterials translational · 2024Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an effort to boost the development of new management strategies for OA, there is currently a shift in focus towards the diagnosis and treatment of early-stage OA. It is important to distinguish diagnosis from classification of early-stage OA. Diagnosis takes place in clinical practice, whereas classification is a process to stratify participants with OA in clinical research. For both purposes, there is an important opportunity for imaging, especially with MRI. The needs and challenges differ for early-stage OA diagnosis versus classification. Although it fulfils the need of high sensitivity and specificity for making a correct diagnosis, implementation of MRI in clinical practice is challenged by long acquisition times and high costs. For classification in clinical research, more advanced MRI protocols can be applied, such as quantitative, contrast-enhanced, or hybrid techniques, as well as advanced image analysis methods including 3D morphometric assessments of joint tissues and artificial intelligence approaches. It is necessary to follow a step-wise and structured approach that comprises, technical validation, biological validation, clinical validation, qualification, and cost-effectiveness, before new imaging biomarkers can be implemented in clinical practice or clinical research.
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Registered trials
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