Evidence map›Paper›PMID 37154859›Full record

ArticleVeterinary research communications2023

Generation of a novel three-dimensional scaffold-based model of the bovine endometrium.

M C Díez, S Przyborski, A Del Cerro, M Alonso-Guervós, T Iglesias-Cabo, S Carrocera, M A García, M Fernández, L Alonso, M Muñoz

Open access · hybridAbstract read
In one paragraph

Article in Veterinary research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Article
  7. Bioengineering-tissue strategies to model mammalian implantationFrontiers in bioengineering and biotechnology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

M C DíezServicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), Área de Genética y Reproducción Animal. Camino de Rioseco, Deva Gijón, 1225 - 33394, Asturias, Spain.
S PrzyborskiDepartment of Bioscience, Durham University, Durham, DH1 3LE, UK.
A Del CerroServicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), Área de Genética y Reproducción Animal. Camino de Rioseco, Deva Gijón, 1225 - 33394, Asturias, Spain.
M Alonso-GuervósOptical Microscopy and Image Processing Unit, Scientific-Technical Services, University of Oviedo, Asturias, Spain.
T Iglesias-CaboScientific-Technical Services, Statistical Consulting Unit, University of Oviedo, Asturias, Spain.
S CarroceraServicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), Área de Genética y Reproducción Animal. Camino de Rioseco, Deva Gijón, 1225 - 33394, Asturias, Spain.
M A GarcíaServicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), Área de Genética y Reproducción Animal. Camino de Rioseco, Deva Gijón, 1225 - 33394, Asturias, Spain.
M FernándezAsociación. Española de Criadores de Ganado Vacuno Selecto Raza Asturiana de los Valles, Asturias, Spain.
L AlonsoMatadero Central de Asturias, Asturias, Spain.
M MuñozServicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), Área de Genética y Reproducción Animal. Camino de Rioseco, Deva Gijón, 1225 - 33394, Asturias, Spain. mmunoz@serida.org.
Servicio Regional de Investigación y Desarrollo Agroalimentario · ESUniversidad de Oviedo · ESDurham University · GB

Funding

Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología PCTI 2021-2023 (GRUPIN: IDI-2021-000102); European Regional Development Fund
6 · The paper itself

Abstract

Bovine in vitro endometrial models that resemble tissue function in vivo are needed to study infertility, long-term uterine alterations induced by pathogens and impact of endocrine disruptor chemicals on reproductive function and other reproductive system complications that cause high economic losses in livestock species. The present study aimed to generate an innovative, reproducible, and functional 3D scaffold-based model of the bovine endometrium structurally robust for long term-culture. We developed a multicellular model containing both endometrial epithelial and stromal cells. Epithelial cells organized to form a luminal-like epithelial layer on the surface of the scaffold. Stromal cells produced their own extracellular matrix forming a stable subepithelial compartment that physiologically resembles the normal endometrium. Both cell types released prostaglandin E

Indexed as

EndometriumOxytocinAnimalsArachidonic AcidCattleDinoprostoneFemaleProstaglandin-E SynthasesArachidonic AcidDinoprostoneOxytocinProstaglandin-E SynthasesCo-cultureEndometriumScaffoldThree-dimensional (3D) cell culture

Identifiers

PMID37154859
PMCPMC10484811
OpenAlexW4375955188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.