ArticleAging2023
Open access · hybridAbstract read
In one paragraph
Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures.Signal transduction and targeted therapy · 2026Article
- Senotherapeutics for metabolic disease and diabetic complications.Journal of internal medicine · 2026Review
- Article
- Elucidating the Role and Mechanism of Alpha-Enolase in Senescent Amelioration via Metabolic Reprogramming.Cell proliferation · 2025Article
- Licoflavone B Suppresses Influenza A Virus by Targeting the Viral RNA-Dependent RNA Polymerase (RdRp).Viruses · 2025Article
- Review
- The impact of a fracture liaison service with in-hospital anti-osteoporosis treatment on subsequent hip fracture and mortality rates-a single-center retrospective study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies.Journal of translational internal medicine · 2025Article
- Emerging insights in senescence: pathways from preclinical models to therapeutic innovations.npj aging · 2024Review
- Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction.Endocrine reviews · 2024Review
- A Pragmatic Approach to Introducing Translational Geroscience Into the Clinic: A Paradigm Based on the Incremental Progression of Aging-Related Clinical Research.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- Cellular senescence and SASP in tumor progression and therapeutic opportunities.Molecular cancer · 2024Review
- Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system.Bone research · 2024Review
- Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions.International journal of molecular sciences · 2024Review
- Osteoimmunology of Fracture Healing.Current osteoporosis reports · 2024Review
- Identified senescence endotypes in aged cartilage are reflected in the blood metabolome.GeroScience · 2024Article
- Article
- Cellular senescence in brain aging and cognitive decline.Frontiers in aging neuroscience · 2023Review
- Cardiovascular benefits and risks associated with calcium, vitamin D, and antiresorptive therapy in the management of skeletal fragility.Women's health (London, England)Review
Corrections and comments
- Update of
Authors and funding
19 authors at 6 institutions in 4 countries.
Parinya SamakkarnthaiDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Dominik SaulDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Lei ZhangInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Zaira AversaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Madison L DoolittleDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Jad G SfeirDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Japneet KaurDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Elizabeth J AtkinsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
James R EdwardsBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7FY, UK.
Graham G RussellBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7FY, UK.
Robert J PignoloDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
James L KirklandDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Tamar TchkoniaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Laura J NiedernhoferInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
David G MonroeDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Nathan K LebrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Joshua N FarrDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Paul D RobbinsInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Sundeep KhoslaDivision of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
Mayo Clinic in Florida · USMayo Clinic · USUniversity of Minnesota · USNuffield Orthopaedic Centre · GBUniversity of Sheffield · GBWinnMed · US
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Zhengdong Zhang · 2017 to 2026
$24.5MEffect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6MEffect of Aging on Preadipocyte DifferentiationR01AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 1997 to 2012
$3.7MSenescence and Growth Differentiation Factors as Modifiers of AgingR01AG055529 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K · 2018 to 2022
$3.1MDefining the interactions of senescent immune cells and skeletal cellsR01AG076515 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2022 to 2026
$2.4MTargeting Cellular Senescence and RAGE in Type 2 DiabetesR01DK128552 · NIDDK · UNIVERSITY OF ARIZONA · PI FARR, JOSHUA NICHOLAS · 2021 to 2025
$2.0MThe Role of miR-219a-5p in Bone MetabolismR01AG063707 · NIA · MAYO CLINIC ROCHESTER · PI MONROE, DAVID G · 2020 to 2024
$1.5MTargeting cellular senescence with senolytics to improve skeletal health in older humansR21AG065868 · NIA · MAYO CLINIC ROCHESTER · PI FARR, JOSHUA NICHOLAS, KHOSLA, SUNDEEP · 2020 to 2021
$419kNIA NIH HHS P01 AG062413NIA NIH HHS R01 AG013925NIA NIH HHS R01 AG055529NIA NIH HHS R01 AG063707NIA NIH HHS R01 AG076515NIA NIH HHS R21 AG065868NIA NIH HHS R37 AG013925NIA NIH HHS U19 AG056278NIDDK NIH HHS R01 DK128552
Abstract
In addition to reducing fracture risk, zoledronic acid has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronic acid could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. To test this, we first performed
Indexed as
Cellular SenescenceSenescence-Associated Secretory PhenotypeAnimalsFibroblastsHumansMiceProteomicsSenotherapeuticsZoledronic AcidSenotherapeuticsZoledronic Acidagingbisphosphonatesbonesenescencesenolytics
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.