Evidence map›Paper›PMID 37154853›Full record

ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2023

Multi-center prospective survey of hepatocellular carcinoma in Kerala: More than 1,200 cases.

Abraham Koshy, Krishnadas Devadas, Charles Panackel, Mathew Philip, N Premaletha, Prakash Zacharias, T M Ramachandran, Rajesh Gopalakrishna, Roy J Mukkada, Cyriac Abby Philips and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Systemic Therapies for Hepatocellular Carcinoma in India.Journal of clinical and experimental hepatology
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Abraham KoshyDepartment of Gastroenterology, VPS Lakeshore Hospital, Kochi, 682 040, India. koshyabe@yahoo.com.ORCID 0000-0002-9997-6569
Krishnadas DevadasDepartment of Gastroenterology, Trivandrum Medical College, Trivandrum, 695 011, India.
Charles PanackelDepartment of Gastroenterology, Aster Medcity, Kochi, 682 027, India.
Mathew PhilipDepartment of Gastroenterology, PVS Memorial Hospital, Kochi, 682 017, India.
N PremalethaDepartment of Gastroenterology, Kottayam Medical College, Kottayam, 686 008, India.
Prakash ZachariasDepartment of Gastroenterology, PVS Memorial Hospital, Kochi, 682 017, India.
T M RamachandranDepartment of Gastroenterology, Calicut Medical College, Calicut, 673 008, India.
Rajesh GopalakrishnaDepartment of Gastroenterology, Amrita Institute of Medical Sciences, Kochi, 682 041, India.
Roy J MukkadaDepartment of Gastroenterology, VPS Lakeshore Hospital, Kochi, 682 040, India.
Cyriac Abby PhilipsDepartment of Gastroenterology, Rajagiri Hospital, Aluva, 683 112, India.
Philip AugustineDepartment of Gastroenterology, Rajagiri Hospital, Aluva, 683 112, India.
Rema KrishnakumarDepartment of Gastroenterology, Moulana Hospital, Perinthalmanna, 679 322, India.
Benoy SebastianDepartment of Gastroenterology, Medical Trust Hospital, Kochi, 682 016, India.
Antony P ChettupuzhaDepartment of Gastroenterology, VPS Lakeshore Hospital, Kochi, 682 040, India.
Shine SadasivanDepartment of Gastroenterology, Amrita Institute of Medical Sciences, Kochi, 682 041, India.
George K ThomasDepartment of Gastroenterology, Pushpagiri Medical College Hospital, Thiruvalla, 689 101, India.
Ismail SiyadDepartment of Gastroenterology, Aster Medcity, Kochi, 682 027, India.
K SandeshDepartment of Gastroenterology, Calicut Medical College, Calicut, 673 008, India.
V B AbhilashDepartment of Gastroenterology, ESIC Hospital, Kollam, 691 002, India.
Rajesh AntonyDepartment of Radiology, VPS Lakeshore Hospital, Kochi, 682 040, India.
Julio C KandathilDepartment of Radiology, VPS Lakeshore Hospital, Kochi, 682 040, India.
Thara PratapDepartment of Radiology, VPS Lakeshore Hospital, Kochi, 682 040, India.
Pushpa MahadevanDepartment of Pathology, VPS Lakeshore Hospital, Kochi, 682 040, India.
Kerala Hepatocellular Carcinoma Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is considered uncommon in India. The aim of this study was to document the demographic characteristics and clinical aspects of HCC in Kerala, India.

methodsA survey of HCC in Kerala was performed. All gastroenterologists in the region were invited. From May 2018 to April 2020, data was collected in a standardized questionnaire.

resultsForty-three doctors from 15 centers contributed the data. Total 1217 patients were analyzed. This is the largest state-wide survey of HCC in India. HCC was more common in men (90%) than in women (p < 0.01). The etiology of liver disease was hepatitis B virus (7%), hepatitis C virus (4%) and alcohol (40%). Diabetes mellitus was present in 64%, hypercholesterolemia in 17% and hypertension in 38%. Obesity was present in 33% and 15% were overweight. Non-alcoholic fatty liver disease (NAFLD) with or without metabolic syndrome was present in 44%. Serum alpha-fetoprotein was > 400 ng/mL in 24%, total tumor diameter was > 5 cm in 59%, portal vein invasion was seen in 35% and distant metastasis was seen in 15%. Specific therapy was given to 52%. Treatments given included liver transplantation (n = 24), liver resection (n = 39) and transarterial chemoembolization (TACE, n = 184). Although the study was not designed to compare survival, patients who had liver transplantation had longer survival (median 69 months) compared to matched patients given only TACE (median 18 months) (p = 0.03).

conclusionHCC is common in Kerala, India. NAFLD has a predominant association with HCC in Kerala. Most of the patients report late when curative treatment is not possible.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsNon-alcoholic Fatty Liver DiseaseFemaleHumansMaleProspective StudiesRetrospective StudiesSurveys and QuestionnairesTreatment OutcomeAlcoholCancerDiabetes mellitusEpidemiologyFatty liverHypertensionLiverMetastasisNeoplasmObesitySurvival

Identifiers

PMID37154853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.