Evidence map›Paper›PMID 37154831›Full record

ReviewDiscover oncology2023

Exosomes and circular RNAs: promising partners in hepatocellular carcinoma from bench to bedside.

Mengyuan Hu, Xue Li, Zhenluo Jiang, Qing Xia, Yaoren Hu, Junming Guo, Liyun Fu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mengyuan HuSchool of Medicine, Ningbo University, Ningbo, 315211, China.
Xue LiWenzhou Medical University, Wenzhou, 325035, China.
Zhenluo JiangDepartment of Emergency, Ningbo No. 2 Hospital, Ningbo, 315010, China.
Qing XiaDepartment of Hepatopancreatobiliary Surgery, Ningbo No. 2 Hospital, Ningbo, 315010, China.
Yaoren HuSchool of Medicine, Ningbo University, Ningbo, 315211, China.
Junming GuoSchool of Medicine, Ningbo University, Ningbo, 315211, China.
Liyun FuSchool of Medicine, Ningbo University, Ningbo, 315211, China. nbfly2009@126.com.
Ningbo No. 2 Hospital · CNNingbo University · CNWenzhou Medical University · CN

Funding

Applied Research Projects on Nonprofit Technology of Zhejiang Province LGF19H160012Key Laboratory of Diagnosis and Treatment of Digestive System tumors of Zhejiang Province 2019E10020Natural Science Foundation of Ningbo 202003N4020Natural Science Foundation of Zhejiang Province LQ19H160007Ningbo Clinical Research Center for Digestive System tumors 2019A21003Ningbo HwaMei Key Research Fund 2020HMZD10, 2019HMZD13Project of NINGBO Leading_ Medical & Health Discipline 2016-S04Zhejiang Medical Scientific Research Foundation 2023KY273
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is characterized by high morbidity and mortality, and a low 5-year survival rate. Exploring the potential molecular mechanisms, finding diagnostic biomarkers with high sensitivity and specificity, and determining new therapeutic targets for HCC are urgently needed. Circular RNAs (circRNAs) have been found to play a key role in the occurrence and development of HCC, while exosomes play an important role in intercellular communication; thus, the combination of circRNAs and exosomes may have inestimable potential in early diagnosis and curative therapy. Previous studies have shown that exosomes can transfer circRNAs from normal or abnormal cells to surrounding or distant cells; thereafter, circRNAs influence target cells. This review summarizes the recent progress regarding the roles of exosomal circRNAs in the diagnosis, prognosis, occurrence and development and immune checkpoint inhibitor and tyrosine kinase inhibitor resistance of HCC to provide inspiration for further research.

Indexed as

BiomarkerCircular RNAExosomeHepatocellular carcinomaImmune therapyMechanism

Identifiers

PMID37154831
PMCPMC10167081
OpenAlexW4375865708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.