Evidence map›Paper›PMID 37154710›Full record

ArticleMicrobiology spectrum2023

The Small Protein ScrA Influences Staphylococcus aureus Virulence-Related Processes via the SaeRS System.

Marcus A Wittekind, Paul Briaud, Jayanna L Smith, Julia R Tennant, Ronan K Carroll

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Activation of themBio · 2025
    Article
  4. Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marcus A WittekindDepartment of Biological Sciences, Ohio University, Athens, Ohio, USA.
Paul BriaudDepartment of Biological Sciences, Ohio University, Athens, Ohio, USA.
Jayanna L SmithDepartment of Biological Sciences, Ohio University, Athens, Ohio, USA.
Julia R TennantDepartment of Biological Sciences, Ohio University, Athens, Ohio, USA.
Ronan K CarrollDepartment of Biological Sciences, Ohio University, Athens, Ohio, USA.ORCID 0000-0001-7090-3414
Ohio University · US

Funding

Investigating the small peptide Tsr37, its role in virulence, and activation of the SaeRS two component system in Staphylococcus aureusR21AI156391 · NIAID · OHIO UNIVERSITY ATHENS · PI CARROLL, RONAN · 2021 to 2022
$405k
NIAID NIH HHS R21 AI156391
6 · The paper itself

Abstract

Staphylococcus aureus is a Gram-positive commensal and opportunistic pathogen able to cause diseases ranging from mild skin infections to life-threatening endocarditis and toxic shock syndrome. The ability to cause such an array of diseases is due to the complex S. aureus regulatory network controlling an assortment of virulence factors, including adhesins, hemolysins, proteases, and lipases. This regulatory network is controlled by both protein and RNA elements. We previously identified a novel regulatory protein called ScrA, which, when overexpressed, leads to the increased activity and expression of the SaeRS regulon. In this study, we further explore the role of ScrA and examine the consequences to the bacterial cell of

Indexed as

Staphylococcal InfectionsStaphylococcus aureusAnimalsBacterial ProteinsMiceTranscription FactorsVirulenceVirulence FactorsBacterial ProteinsTranscription FactorsVirulence Factorsclumpinggene regulationhemolysisSaeRSScrAStaphylococcus aureustwo-component systemvirulence

Identifiers

PMID37154710
PMCPMC10269730
OpenAlexW4375860020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.