Evidence map›Paper›PMID 37154694›Full record

ReviewJournal of bacteriology2023

Carbon Monoxide-Sensing Transcription Factors: Regulators of Microbial Carbon Monoxide Oxidation Pathway Gene Expression.

Matthew R Dent, Brian R Weaver, Madeleine G Roberts, Judith N Burstyn

Open access · greenAbstract readReview
In one paragraph

Review in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Thermodynamic Evaluation of Dual Substrate Growth.Biotechnology and bioengineering · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Carbon Monoxide and Prokaryotic Energy Metabolism.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Gas Tunnel Engineering of Prolyl Hydroxylase Reprograms Hypoxia Signaling in Cells.Angewandte Chemie (International ed. in English) · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Membrane-Bound Redox Enzyme CytochromeInternational journal of molecular sciences · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew R DentHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7704-4867
Brian R WeaverDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-6991-014X
Madeleine G RobertsDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-4321-1249
Judith N BurstynDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-3245-5563
University of Wisconsin–Madison · USUniversity of Pittsburgh · US

Funding

Development of a carbon monoxide scavenging hemoprotein as a novel antidotal therapy to treat inhaled CO poisoningF32HL162381 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2022 to 2022
$77k
NHLBI NIH HHS F32 HL162381
6 · The paper itself

Abstract

Carbon monoxide (CO) serves as a source of energy and carbon for a diverse set of microbes found in anaerobic and aerobic environments. The enzymes that bacteria and archaea use to oxidize CO depend upon complex metallocofactors that require accessory proteins for assembly and proper function. This complexity comes at a high energetic cost and necessitates strict regulation of CO metabolic pathways in facultative CO metabolizers to ensure that gene expression occurs only when CO concentrations and redox conditions are appropriate. In this review, we examine two known heme-dependent transcription factors, CooA and RcoM, that regulate inducible CO metabolism pathways in anaerobic and aerobic microorganisms. We provide an analysis of the known physiological and genomic contexts of these sensors and employ this analysis to contextualize known biochemical properties. In addition, we describe a growing list of putative transcription factors associated with CO metabolism that potentially use cofactors other than heme to sense CO.

Indexed as

Carbon MonoxideTranscription FactorsBacterial ProteinsGene ExpressionHemeOxidation-ReductionBacterial ProteinsCarbon MonoxideHemeTranscription Factorscarbon monoxidegene regulationhememetabolismmetallobiochemistrytranscription factors

Identifiers

PMID37154694
PMCPMC10210986
OpenAlexW4375861060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.