Evidence map›Paper›PMID 37154678›Full record

ArticleNano letters2023

Targeted Enzyme Activity Imaging with Quantitative Phase Microscopy.

Swati Tanwar, Lintong Wu, Noah Zahn, Piyush Raj, Behnaz Ghaemi, Arnab Chatterjee, Jeff W M Bulte, Ishan Barman

Abstract read
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Raman Imaging of Targeted Drug Delivery with DNA-Based Nano-Optical Devices.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Swati TanwarDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0002-0430-1922
Lintong WuDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Noah ZahnDepartment of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Piyush RajDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0002-1488-9475
Behnaz GhaemiThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA.ORCID 0000-0003-2220-0428
Arnab ChatterjeeDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Jeff W M BulteDepartment of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0003-1202-1610
Ishan BarmanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0003-0800-0825

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Spectroscopy assisted mechano-chemical phenotype recognition nanoscopeDP2GM128198 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARMAN, ISHAN · 2017 to 2017
$2.5M
Intracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor TherapyR01EB030376 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2020 to 2024
$2.1M
Determination of functional and molecular biomarkers of treatment resistance with multimodal optical spectroscopyR01CA238025 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI RAJARAM, NARASIMHAN · 2019 to 2024
$2.0M
NCI NIH HHS R01 CA238025NIBIB NIH HHS P41 EB015871NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB030376NIGMS NIH HHS DP2 GM128198
6 · The paper itself

Abstract

Quantitative phase imaging (QPI) is a powerful optical imaging modality for label-free, rapid, and three-dimensional (3D) monitoring of cells and tissues. However, molecular imaging of important intracellular biomolecules such as enzymes remains a largely unexplored area for QPI. Herein, we introduce a fundamentally new approach by designing QPI contrast agents that allow sensitive detection of intracellular biomolecules. We report a new class of bio-orthogonal QPI-nanoprobes for

Indexed as

MicroscopyNanoparticlesOptical ImagingSilicon DioxideSilicon DioxideBio-orthogonal reactionsEnzymesQuantitative phase imagingRefractive index imagingSilica nanoparticlesTargeted imaging

Identifiers

PMID37154678
PMCPMC10798004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.