Trial reportAmerican journal of respiratory and critical care medicine2023
Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial.
Open access · hybridAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 5 pooled it
5.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Safety of intravascular administration of umbilical-cord-derived mesenchymal stromal cells: an updated systematic review and meta-analysis.Stem cells translational medicine · 2026Pooled it
- Therapeutic potential of mesenchymal stromal cells in COVID-19: a meta-analysis of clinical trials conducted since the pandemic onset.Stem cell research & therapy · 2026Pooled it
- Efficacy and safety of mesenchymal stem/stromal cells and their derived extracellular vesicles for acute respiratory distress syndrome: a systematic review and meta-analysis.Stem cell research & therapy · 2025Pooled it
- Efficacy and safety of stem cell therapy vs. standard of care in patients diagnosed with acute respiratory distress syndrome: an updated systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2025Pooled it
- Mesenchymal Stem Cells on Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Stem cell reviews and reports · 2024Pooled it
- Cellular immunotherapy for COVID-19-induced acute respiratory distress syndrome: Results of the CIRCA-19 phase 1 safety and phase 2 randomized controlled trials.Stem cell reports · 2026Trial
- Long-term outcomes of mesenchymal stem cell therapy in severe COVID-19 patients: 3-year follow-up of a randomized, double-blind, placebo-controlled trial.Stem cell research & therapy · 2025Trial
- The Acute Respiratory Distress Syndrome (ARDS): epidemiology, etiology, molecular mechanisms, diagnosis and therapeutic strategies.Molecular biomedicine · 2026Review
- Bone Marrow Mesenchymal Stem Cell Extracellular Vesicle Treatment of Respiratory Failure from COVID-19: Endpoint Analysis of Expanded Access Safety Trial.Stem cell reviews and reports · 2026Article
- The multifaceted role of mesenchymal stem cells in infectious diseases: antimicrobial properties, immunomodulation and tissue repair.Frontiers in immunology · 2026Review
- From development to regeneration: the endothelial interface in lung injury and repair.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- Living bio-drug therapies using mesenchymal stem cells and exosomes for mechanically ventilated patients with acute respiratory distress syndrome: A systematic review and meta-analysis.World journal of stem cells · 2025Article
- Mesenchymal stem cell therapies for ARDS: translational promise and challenges.Stem cell research & therapy · 2025Review
- Dimethyl sulfoxide in cryopreserved mesenchymal stromal cell therapy products: is there a safety risk to patients?Journal of translational medicine · 2025Review
- Initial or continuous coculture with umbilical cord-derived mesenchymal stromal cells facilitates in vitro expansion of human regulatory T-cell subpopulations.Stem cells translational medicine · 2025Article
- Efficacy and safety of mesenchymal stem cell therapy for acute respiratory distress syndrome-a systematic review and meta-analysis.Journal of thoracic disease · 2024Article
- Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19.World journal of stem cells · 2024Review
- Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?American journal of respiratory and critical care medicine · 2024Article
- Vascular leak in sepsis: physiological basis and potential therapeutic advances.Critical care (London, England) · 2024Review
- Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS).Respiratory research · 2024Review
Corrections and comments
- Commented on by
Authors and funding
32 authors at 17 institutions in 4 countries.
Ellen A GormanWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-6020-1985
Jennifer RynneCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-8945-8434
Hannah J GardinerWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Anthony J RostronSunderland Royal Hospital, South Tyneside and Sunderland National Health Service Foundation Trust, Sunderland, United Kingdom.ORCID 0000-0002-9336-1723
Jonathan Bannard-SmithDepartment of Critical Care, Manchester Royal Infirmary, Manchester, United Kingdom.ORCID 0000-0001-7120-480X
Andrew M BentleyAcute Intensive Care Unit, Wythenshawe Hospital, Manchester, United Kingdom.ORCID 0000-0002-6883-9246
David BrealeyUniversity College Hospital London, London, United Kingdom.ORCID 0000-0002-1982-3379
Christina CampbellNorthern Ireland Clinical Trials Unit, Belfast, United Kingdom.ORCID 0000-0002-8446-523X
Gerard CurleyRoyal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0003-0271-195X
Mike ClarkeNorthern Ireland Clinical Trials Unit, Belfast, United Kingdom.ORCID 0000-0002-2926-7257
Ahilanadan DushianthanUniversity Hospital Southampton, Southampton, United Kingdom.ORCID 0000-0002-0165-3359
Phillip HopkinsKing's Trauma Centre, King's College Hospital, London, United Kingdom.ORCID 0000-0002-3713-8391
Colette JacksonNorthern Ireland Clinical Trials Unit, Belfast, United Kingdom.
Kallirroi KefelaDepartment of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Anna KrasnodembskayaWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-2380-5069
John G LaffeyRegenerative Medicine Institute at CÚRAM Centre for Research in Medical Devices, University of Galway, Galway, Ireland.ORCID 0000-0002-1246-9573
Cliona McDowellNorthern Ireland Clinical Trials Unit, Belfast, United Kingdom.
Margaret McFarlandDepartment of Critical Care, Belfast Health and Social Care Trust, Belfast, United Kingdom.
Jamie McFerranNorthern Ireland Clinical Trials Unit, Belfast, United Kingdom.
Peter McGuiganWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Gavin D PerkinsCritical Care Unit, University Hospitals Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-3027-7548
Jonathan SilversidesWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-9562-5462
Jon SmytheNational Health Service Blood and Transplant, Oxford, United Kingdom.
Jacqui ThompsonNational Health Service Blood and Transplant, Birmingham, United Kingdom.
William S TunnicliffeQueen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Ingeborg D M WeltersIntensive Care Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.ORCID 0000-0002-3408-8798
Laura Amado-RodríguezCentro de Investigación Biomédica en Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-8793-0213
Guillermo AlbaicetaCentro de Investigación Biomédica en Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-9276-3253
Barry WilliamsIndependent Patient and Public Representative, Sherborne, United Kingdom.
Manu Shankar-HariCentre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-5338-2538
Daniel F McAuleyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-3283-1947
Cecilia M O'KaneWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-7138-5396
Queen's University Belfast · GBNational Health Service · GBCentre for Inflammation Research · GBBelfast Health and Social Care Trust · GBEdinburgh Royal Infirmary · GBInstituto de Salud Carlos III · ESKing's College Hospital · GBManchester Royal Infirmary · GBOllscoil na Gaillimhe – University of Galway · IEQueen Elizabeth Hospital Birmingham · GBRoyal College of Surgeons in Ireland · IEUniversidad de Oviedo · ESUniversity College Hospital · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Alabama at Birmingham Hospital · USUniversity of Liverpool · GBWythenshawe Hospital · GB
Funding
Medical Research Council MR/M009149/1Medical Research Council MR/R025096/1Medical Research Council MR/S009426/1Wellcome Trust 106939/Z/15/Z
Abstract
PubMed holds no abstract for this paper.
Indexed as
COVID-19Lung Diseases, InterstitialRespiratory Distress SyndromeHumansLungStromal Cellsacute respiratory distress syndromeclinical trialcoronavirus diseasemesenchymal stromal cells
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.