ArticleMagnetic resonance in medicine2023
Isolation of amide proton transfer effect and relayed nuclear Overhauser enhancement effect at -3.5ppm using CEST with double saturation powers.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Enhanced Quantitative Phosphocreatine MR Imaging of Skeletal Muscle Using a Global-Local Two-Branch Deep Learning Model.Magnetic resonance in medicine · 2026Article
- Denoising Low-Power CEST Imaging Using a Deep Learning Approach With a Dual-Power Feature Preparation Strategy.Magnetic resonance in medicine · 2026Article
- Chemical exchange saturation transfer MRI for neurodegenerative diseases: An update on clinical and preclinical studies.Neural regeneration research · 2026Article
- Interpreting amide proton transfer-weighted imaging contrast between normal and tumor brain tissues using the asymmetry analysis method at 4.7 T.Magnetic resonance in medicine · 2026Article
- Double-Step R1rho-Based Lorentzian Fitting (DROF): A New CEST Analysis Approach and Its Comparison With Existing Methods.NMR in biomedicine · 2025Article
- CESTsimu: An open-source GUI for spectral and spatial CEST simulation.Magnetic resonance in medicine · 2025Article
- Improving quantification accuracy of a nuclear Overhauser enhancement signal at -1.6 ppm at 4.7 T using a machine learning approach.Physics in medicine and biology · 2025Article
- Enhancing amide proton transfer imaging in ischemic stroke using a machine learning approach with partially synthetic data.NMR in biomedicine · 2025Article
- A Denoising Convolutional Autoencoder for SNR Enhancement in Chemical Exchange Saturation Transfer imaging: (DCAE-CEST).bioRxiv : the preprint server for biology · 2024Article
- Specific and rapid guanidinium CEST imaging using double saturation power and QUASS analysis in a rodent model of global ischemia.Magnetic resonance in medicine · 2024Article
- Evaluation of the molecular origin of amide proton transfer-weighted imaging.Magnetic resonance in medicine · 2024Article
- Multiparametric CEST MRI for Time-Associated Characterization of Acute Ischemic Stroke: NOE (-3.5 ppm) Signal as a Potential Imaging Biomarker.Molecular imagingArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeQuantifications of amide proton transfer (APT) and nuclear Overhauser enhancement (rNOE(-3.5)) mediated saturation transfer with high specificity are challenging because their signals measured in a Z-spectrum are overlapped with confounding signals from direct water saturation (DS), semi-solid magnetization transfer (MT), and CEST of fast-exchange pools. In this study, based on two canonical CEST acquisitions with double saturation powers (DSP), a new data-postprocessing method is proposed to specifically quantify the effects of APT and rNOE.
methodsFor CEST imaging with relatively low saturation powers (
resultsThe simulations show that DSP-CEST can quantify the effects of APT and rNOE and substantially eliminate the confounding signals. The in vivo experiments demonstrate that the proposed DSP-CEST method is feasible for the imaging of tumors.
conclusionThe data-postprocessing method proposed in this study can quantify the APT and rNOE effects with considerably increased specificities and a reduced cost of imaging time.
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