Evidence map›Paper›PMID 37153733›Full record

ArticleTheranostics2023

A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis.

Qian Guo, Mingyang Xin, Qingchun Lu, Dechun Feng, Vicky Yang, Lee F Peng, Kelly A Whelan, Wenhui Hu, Sheng Wu, Xiaofeng Yang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  6. Article
  7. Review
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  10. Article
  11. Updated mechanisms of MASLD pathogenesis.Lipids in health and disease · 2024
    Review
  12. Frontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Qian GuoDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Mingyang XinDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Qingchun LuDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Dechun FengLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Vicky YangDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Lee F PengDivision of Hepatology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Kelly A WhelanDepartment of Cancer and Cellular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Wenhui HuDepartment of Cardiovascular Sciences/Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Sheng WuDepartment of Cardiovascular Sciences/Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Xiaofeng YangDepartment of Cardiovascular Sciences/Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Hong WangDepartment of Cardiovascular Sciences/Center for Metabolic Disease Research, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Brad S RothbergDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Ana M GameroDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Glenn S GerhardDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Bin GaoLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Ling YangDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Temple University · USNational Institutes of Health · US

Funding

Investigating the role of mitochondria in Eosinophilic Esophagitis pathogenesis.R01DK121159 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WHELAN, KELLY A · 2019 to 2023
$2.4M
Regulation and Function of Thioredoxin Interacting Protein (Txnip) in Nonalcoholic Steatohepatitis (NASH)R01DK134494 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI Ling Yang · 2023 to 2026
$1.4M
Identification and Characterization of Novel Metabolic Regulators in Mouse and Human LiverK22HL139921 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI YANG, LING · 2018 to 2020
$731k
NHLBI NIH HHS K22 HL139921NIDDK NIH HHS R01 DK121159NIDDK NIH HHS R01 DK134494
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Non-alcoholic Fatty Liver DiseaseAnimalsApoptosisCarrier ProteinsInflammationLiverMiceMice, Inbred C57BLSignal TransductionThioredoxinsCarrier ProteinsThioredoxinsTxnip protein, mouseCHOPE3 ligaseNASHTXNIPUbiquitination

Identifiers

PMID37153733
PMCPMC10157740
OpenAlexW4375955962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.