Evidence map›Paper›PMID 37153662›Full record

SynthesisFrontiers in neurology2023

Risks of suicide in migraine, non-migraine headache, back, and neck pain: a systematic review and meta-analysis.

Alec Giakas, Kiersten Mangold, Anthony Androulakis, Noah Hyduke, Igor Galynker, Melinda Thiam, Guoshuai Cai, X Michelle Androulakis

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Suicidal ideation and medical comorbidity: a hidden problem.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Article
  10. Placebo and nocebo effect in pain.Handbook of clinical neurology · 2025
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alec GiakasDepartment of Orthopedic Surgery, University of South Carolina School of Medicine, Columbia, SC, United States.
Kiersten MangoldDepartment of Exercise Science, University of South Carolina, Columbia, SC, United States.
Anthony AndroulakisDepartment of Biological Sciences, University of South Carolina, Columbia, SC, United States.
Noah HydukeDepartment of Psychiatry, University of South Carolina School of Medicine, Columbia, SC, United States.
Igor GalynkerDepartment of Psychiatry, Beth Israel Medical Center, New York, NY, United States.
Melinda ThiamDepartment of Psychiatry, New Mexico VA Hospital System, Albuquerque, NM, United States.
Guoshuai CaiDepartment of Environmental Health Sciences, University of South Carolina, Columbia, SC, United States.
X Michelle AndroulakisDepartment of Neurology, Columbia VA Healthcare System, Columbia, SC, United States.
University of South Carolina · USMount Sinai Beth Israel · USNew Mexico VA Health Care System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To conduct a systematic review and meta-analysis on suicidal ideation, attempts, and death in patients with head, neck, and back pain. Method: Search was performed using PubMed, Embase, and Web of Science from the date of the first available article through September 31, 2021. A random effects model was used to estimate the pooled odds ratios (ORs) and 95% confidence intervals (95% CI) for the association between suicidal ideation and/or attempt and head, back/neck pain conditions. Articles describing non-migraine headache disorders and death by suicide were also reviewed but not included in the meta-analysis due to an insufficient number of studies. Results: A total of 20 studies met criteria for systemic review. A total of 186,123 migraine patients and 135,790 of neck/back pain patients from 11 studies were included in the meta-analysis. The meta-analysis showed that the estimated risk of combined suicidal ideation and attempt in migraine [OR 2.49; 95% CI: 2.15-2.89] is greater than that in back/neck pain pain [OR 2.00; 95% CI: 1.63-2.45] compared to non-pain control groups. Risk of suicide ideation/planning is 2 folds higher [OR: 2.03; 95% CI: 1.92-2.16] and risk of suicide attempt is more than 3 folds higher [OR: 3.47; 95% CI: 2.68-4.49] in migraine as compared to healthy controls. Conclusion: There is an elevated risk of suicidal ideation and attempt in both migraine and neck/back pain patients in comparison to healthy controls, and this risk is particularly higher among migraine patients. This study underscores the critical need for suicide prevention in migraine patients.

Indexed as

chronic back painchronic neck painheadachemigrainesuicide

Identifiers

PMID37153662
PMCPMC10157105
OpenAlexW4366548516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.