Evidence map›Paper›PMID 37153579›Full record

ArticleFrontiers in immunology2023

Serum amyloid A proteins reduce bone mass during mycobacterial infections.

Ana Cordeiro Gomes, Daniela Monteiro Sousa, Tiago Carvalho Oliveira, Óscar Fonseca, Ricardo J Pinto, Diogo Silvério, Ana Isabel Fernandes, Ana C Moreira, Tânia Silva, Maria José Teles and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Ana Cordeiro Gomesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Daniela Monteiro Sousai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Tiago Carvalho Oliveirai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Óscar Fonsecai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Ricardo J Pintoi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Diogo Silvérioi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Ana Isabel Fernandesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Ana C Moreirai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Tânia Silvai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Maria José Telesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Luísa Pereirai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Margarida Saraivai3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Meriem Lamgharii3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Maria Salomé Gomesi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Universidade do Porto · PTi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTUniversity of Aveiro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Osteopenia has been associated to several inflammatory conditions, including mycobacterial infections. How mycobacteria cause bone loss remains elusive, but direct bone infection may not be required. Methods: Genetically engineered mice and morphometric, transcriptomic, and functional analyses were used. Additionally, inflammatory mediators and bone turnover markers were measured in the serum of healthy controls, individuals with latent tuberculosis and patients with active tuberculosis. Results and discussion: We found that infection with

Indexed as

Mycobacterium tuberculosisSerum Amyloid A ProteinAnimalsBone and BonesCytokinesHumansMacrophagesMiceTumor Necrosis Factor-alphaCytokinesSerum Amyloid A ProteinTumor Necrosis Factor-alphabone lossinflammationmycobacteriaSAAtuberculosis

Identifiers

PMID37153579
PMCPMC10161249
OpenAlexW4366775502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.