Evidence map›Paper›PMID 37153574›Full record

ReviewFrontiers in immunology2023

Opportunities for Treg cell therapy for the treatment of human disease.

Jeffrey A Bluestone, Brent S McKenzie, Joshua Beilke, Fred Ramsdell

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

  1. Review
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  5. Decoding TNF receptor superfamily control of CD4Cell communication and signaling : CCS · 2026
    Review
  6. Dual CD8 and TCR editing in regulatory T cells mediates HLA-A2-restricted tissue-specific homing.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Research Progress of Molecular HDrug design, development and therapy · 2026
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeffrey A BluestoneSonoma Biotherapeutics, South San Francisco, CA, United States.
Brent S McKenzieSonoma Biotherapeutics, South San Francisco, CA, United States.
Joshua BeilkeSonoma Biotherapeutics, South San Francisco, CA, United States.
Fred RamsdellSonoma Biotherapeutics, South San Francisco, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population can develop in the thymus and in the peripheral tissues of the immune system through the expression of an epigenetically stabilized transcription factor, FOXP3. Treg cells mediate their tolerogenic effects using multiple modes of action, including the production of inhibitory cytokines, cytokine starvation of T effector (

Indexed as

Immune System DiseasesT-Lymphocytes, RegulatoryCD4-Positive T-LymphocytesCytokinesHumansImmune ToleranceImmunosuppression TherapyCytokinesautoimmunityFoxp3immune regulationimmune toleranceTreg

Identifiers

PMID37153574
PMCPMC10154599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.