Evidence map›Paper›PMID 37153111›Full record

ArticleJournal of the Endocrine Society2023

Exploratory Study of the Association of Genetic Factors With Recovery of Adrenal Function in Cushing Disease.

Matthew H Nguyen, Wei Zhang, Nathan Pankratz, John Lane, Prashant Chitiboina, Fabio R Faucz, James L Mills, Constantine A Stratakis, Christina Tatsi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Neonatologists' practices in screening and managing corticosteroid-induced adrenal insufficiency in the NICU- a multicenter study.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Matthew H NguyenUnit on Hypothalamic and Pituitary Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-4846-2058
Wei ZhangAcademy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100045, China.ORCID https://orcid.org/0000-0002-4315-8380
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA.ORCID https://orcid.org/0000-0001-5958-693X
John LaneDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55454, USA.
Prashant ChitiboinaNeurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-9349-4756
Fabio R FauczMolecular Genomics Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-7959-9842
James L MillsEpidemiology Branch, Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0003-4496-332X
Constantine A StratakisUnit on Hypothalamic and Pituitary Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-4058-5520
Christina TatsiUnit on Hypothalamic and Pituitary Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-2882-4584
National Institutes of Health · USUniversity of Minnesota Medical Center · USChinese Academy of Sciences · CN

Funding

Improved Diagnosis and Treatment of Cushing's DiseaseZIANS003150 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI CHITTIBOINA, PRASHANT · 2015 to 2025
$13.7M
Evaluation of Hypothalamic and Pituitary DisordersZIAHD009017 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI TATSI, CHRISTINA · 2022 to 2025
$3.8M
Cushing's Disease Whole Exome Sequencing StudyZIAHD008939 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MILLS, JAMES · 2014 to 2023
$1.2M
6 · The paper itself

Abstract

Successful treatment of endogenous Cushing disease (CD) is often followed by a period of adrenal insufficiency (AI). We performed an exploratory study on genetic factors potentially involved in the hypothalamic-pituitary-adrenal (HPA) axis recovery in patients with CD after remission. We identified 90 patients who achieved remission after surgery and had a minimum of 3 months follow-up. Variants in a selected panel of genes that were rare in the general population and predicted as damaging

Indexed as

adrenal insufficiencyCushing diseasegeneticsHPA axispituitary

Identifiers

PMID37153111
PMCPMC10161137
OpenAlexW4366986115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.