ArticleAnnals of gastroenterological surgery2023
Genomic landscape of pancreatic cancer in the Japanese version of the Cancer Genome Atlas.
Article in Annals of gastroenterological surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comparison of Familial and Sporadic Pancreatic Cancer: Clinicopathological and Genomic Features.Annals of surgical oncology · 2026Article
- Stratification of G2 pancreatic neuroendocrine tumors using a Ten Percent Ki-67 index cut-off based on clinicopathological and molecular analyses.Scientific reports · 2025Article
- Impairment of perioperative activities of daily living is associated with poor prognosis following pancreatectomy for pancreatic cancer.Langenbeck's archives of surgery · 2024Article
- Copy Number Variations in Pancreatic Cancer: From Biological Significance to Clinical Utility.International journal of molecular sciences · 2023Review
- Genomic landscape of pancreatic cancer in the Japanese version of the Cancer Genome Atlas.Annals of gastroenterological surgery · 2023Article
- Characterization of pancreatic cancer with ultra-low tumor mutational burden.Scientific reports · 2023Article
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Authors and funding
10 authors.
Funding
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Abstract
Background: Pancreatic cancer (PC) is one of the most aggressive cancers worldwide. Although many studies have investigated genomic alterations, the genomic landscape of Japanese PC patients has not been fully elucidated. Methods: We used whole-exome sequencing, cancer gene panel deep-sequencing, and microarray gene expression profiling data derived from the Japanese version of the Cancer Genome Atlas (JCGA) in 93 PC cases. Results: Somatic driver mutations were identified in 65.6% of samples in 19 genes. The median tumor mutation burden (TMB) value was 0.24 Muts/Mb (interquartile range, 0.15-0.64 Muts/Mb). The commonly mutated genes were Conclusion: The present results from the JCGA dataset constitute a fundamental resource for genomic medicine for PC patients, especially in Japan.
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