Evidence map›Paper›PMID 37152444›Full record

ArticleNeurology. Genetics2023

CircPDS5B Reduction Improves Angiogenesis Following Ischemic Stroke by Regulating MicroRNA-223-3p/NOTCH2 Axis.

Ling Kui, Zongyu Li, Guoyun Wang, Xuzhen Li, Feng Zhao, Yinming Jiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ling KuiDehong People's Hospital (Z.L., F.Z.), Mangshi; Shenzhen Qianhai Shekou Free Trade Zone Hospital (L.K., G.W., Y.J.), Shenzhen; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and State Key Laboratory of Biological Big Data in Yunnan Province (X.L.), Yunnan Agricultural University, Kunming, China.ORCID https://orcid.org/0000-0002-1416-1601
Zongyu LiDehong People's Hospital (Z.L., F.Z.), Mangshi; Shenzhen Qianhai Shekou Free Trade Zone Hospital (L.K., G.W., Y.J.), Shenzhen; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and State Key Laboratory of Biological Big Data in Yunnan Province (X.L.), Yunnan Agricultural University, Kunming, China.
Guoyun WangDehong People's Hospital (Z.L., F.Z.), Mangshi; Shenzhen Qianhai Shekou Free Trade Zone Hospital (L.K., G.W., Y.J.), Shenzhen; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and State Key Laboratory of Biological Big Data in Yunnan Province (X.L.), Yunnan Agricultural University, Kunming, China.
Xuzhen LiDehong People's Hospital (Z.L., F.Z.), Mangshi; Shenzhen Qianhai Shekou Free Trade Zone Hospital (L.K., G.W., Y.J.), Shenzhen; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and State Key Laboratory of Biological Big Data in Yunnan Province (X.L.), Yunnan Agricultural University, Kunming, China.
Feng ZhaoDehong People's Hospital (Z.L., F.Z.), Mangshi; Shenzhen Qianhai Shekou Free Trade Zone Hospital (L.K., G.W., Y.J.), Shenzhen; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and State Key Laboratory of Biological Big Data in Yunnan Province (X.L.), Yunnan Agricultural University, Kunming, China.
Yinming JiaoDehong People's Hospital (Z.L., F.Z.), Mangshi; Shenzhen Qianhai Shekou Free Trade Zone Hospital (L.K., G.W., Y.J.), Shenzhen; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan and State Key Laboratory of Biological Big Data in Yunnan Province (X.L.), Yunnan Agricultural University, Kunming, China.
Yunnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Ischemic stroke (IS) is responsible for major causes of global death and disability, for which promoting angiogenesis is a promising therapeutic strategy. This study analyzed circular RNA PDS5B (circPDS5B) and its related mechanisms in angiogenesis in IS. Methods: In the permanent middle cerebral artery occlusion (pMCAO) mouse model, circPDS5B, microRNA (miR)-223-3p, and NOTCH2 levels were checked. By testing neurologic function, neuronal apoptosis, and expression of angiogenesis-related proteins in pMCAO mice, the protective effects of circPDS5B knockdown were probed. In human brain microvascular endothelial cells (HBMECs) under oxygen-glucose deprivation (OGD) conditions, the effects of circPDS5B, miR-223-3p, and NOTCH2 on angiogenesis were studied by measuring cellular activities. Results: The increase of circPDS5B and NOTCH2 expression and the decrease of miR-223-3p expression were examined in pMCAO mice. Reducing circPDS5B expression indicated protection against neurologic dysfunction, apoptosis, and angiogenesis impairment. For circPDS5B-depleted or miR-223-3p-restored HBMECs under OGD treatment, angiogenesis was promoted. MiR-223-3p inhibition-associated reduction of angiogenesis could be counteracted by knocking down NOTCH2. CircPDS5B depletion-induced angiogenesis in OGD-conditioned HBMECs was repressed after overexpressing NOTCH2. Discussion: In IS, the expression of circPDS5B was upregulated, and miR-223-3p inhibited HBMECs activity and promoted NOTCH2 expression, thus promoting IS. CircPDS5B reduction improves angiogenesis following ischemic stroke by regulating microRNA-223-3p/NOTCH2 axis.

Identifiers

PMID37152444
PMCPMC10162703
OpenAlexW4372221763

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.