Evidence map›Paper›PMID 37152432›Full record

ArticleFrontiers in molecular neuroscience2023

Cingulate protein arginine methyltransferases 1 regulates peripheral hypersensitivity

Cheng Wu, Hui-Fang Shang, Yong-Jie Wang, Jing-Hua Wang, Zhen-Xing Zuo, Yan-Na Lian, Li Liu, Chen Zhang, Xiang-Yao Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Cheng WuZhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, China.
Hui-Fang ShangInternational Institutes of Medicine, The Forth Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Yiwu, China.
Yong-Jie WangInternational Institutes of Medicine, The Forth Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Yiwu, China.
Jing-Hua WangInternational Institutes of Medicine, The Forth Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Yiwu, China.
Zhen-Xing ZuoDepartment of Neurosurgery, Tenth People's Hospital, Shanghai, China.
Yan-Na LianInternational Institutes of Medicine, The Forth Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Yiwu, China.
Li LiuCore Facilities of the School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Chen ZhangSchool of Basic Medical Sciences, Capital Medical University, Beijing, China.
Xiang-Yao LiZhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, China.
Zhejiang Lab · CNZhejiang University · CNCapital Medical University · CNShanghai Tenth People's Hospital · CNUniversity of Edinburgh · GBZhejiang University-University of Edinburgh Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The deficit of fragile X messenger ribonucleoprotein (FMRP) leads to intellectual disability in human and animal models, which also leads to desensitization of pain after nerve injury. Recently, it was shown that the protein arginine methyltransferases 1 (PRMT1) regulates the phase separation of FMRP. However, the role of PRMT1 in pain regulation has been less investigated. Here we showed that the downregulation of PRMT1 in the anterior cingulate cortex (ACC) contributes to the development of peripheral pain hypersensitivity. We observed that the peripheral nerve injury decreased the expression of PRMT1 in the ACC; knockdown of the PRMT1

Indexed as

cingulate cortexfragile X messenger ribonucleoproteinperipheral hypersensitivityperipheral nerve injuryprotein arginine methyltransferases 1

Identifiers

PMID37152432
PMCPMC10158607
OpenAlexW4366594587

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.