Evidence map›Paper›PMID 37152296›Full record

ArticleFood & nutrition research2023

Dong Yeop Shin, Byeong Soo Kim, Hak Yong Lee, Young Mi Park, Yong Wan Kim, Min Jung Kim, Hye Jeong Yang, Mi Seong Kim, Jun Sang Bae

Open access · goldAbstract read
In one paragraph

Article in Food & nutrition research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Nutrients · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Dong Yeop ShinDepartment of Companion and Laboratory Animal Science, Kongju National University, Yesan, South Korea.
Byeong Soo KimDepartment of Companion and Laboratory Animal Science, Kongju National University, Yesan, South Korea.
Hak Yong LeeINVIVO Co. Ltd., Nonsan, South Korea.
Young Mi ParkINVIVO Co. Ltd., Nonsan, South Korea.
Yong Wan KimDaegu Cancer Center, Research and Development Unit, DongSung Pharmaceuticals Co. Ltd., Daegu, South Korea.
Min Jung KimKorea Food Research Institute, Iseo, South Korea.
Hye Jeong YangKorea Food Research Institute, Iseo, South Korea.
Mi Seong KimDepartment of Oral Biochemistry, College of Dentistry, Institute of Biomaterial-Implant, Wonkwang University, Iksan, South Korea.
Jun Sang BaeDepartment of Pathology, College of Korean Medicine, Wonkwang University, Iksan, South Korea.
Kongju National University · KRKorea Food Research Institute · KRKukdong Communication (South Korea) · KRWonkwang University · KRCancer Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objective: We evaluated the immune-enhancing effect of EA treatment in a cyclophosphamide (Cy)-induced immunosuppressed rat model. Design: We analyzed the immune enhancement effect of EA on macrophages by western blotting. In addition, cell viability and natural killer (NK) cell activity were analyzed in splenocytes following EA treatment. For Results: EA significantly increased cell viability and phospho-nuclear factor-kappa B and phospho-extracellular signal-regulated kinase protein levels in the macrophages. EA significantly increased NK cell activity in splenocytes compared with the control group. In Cy-induced immunosuppressed rats, EA administration increased spleen tissue weight and the contents of leukocytes, lymphocytes, granulocytes, intermediate cells, and plasma cytokines (tumor necrosis factor-α and interferon-γ). In addition, improvement in the damaged spleen tissue was observed. Conclusions: These findings confirm that EA exerts an immune-enhancing effect, thereby suggesting its potential as an immunostimulatory agent or functional food.

Indexed as

cyclophosphamideEuonymus alatus (Thunb.) Sieboldimmune enhancementimmunosuppressed ratmacrophage

Identifiers

PMID37152296
PMCPMC10155189
OpenAlexW4366599888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.